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α-亚氨基膦酸酯的合成与生物活性研究
发表时间：2008-04-30 浏览量：2183 下载量：680
| 全部作者： | 陈卓，谷利军，高兴文，卢平，徐应淑，宋宝安，金林红 |
| 作者单位： | 贵州大学精细化工研究开发中心，教育部绿色农药与农业生物工程重点实验室，贵州省精细化工重点实验室 |
| 摘 要： | α-氨基膦酸及其衍生物已成为国内外关注的热点，它们作为天然氨基酸的类似物,在医药、农药中起着越来越重要的作用。本文以苯甲酰氯或含氟苯甲酰氯为原料，设计合成了9个未见文献报道的（含氟）α-亚氨基膦酸酯类化合物，产率49.2％～60.6%。用元素分析、IR、1H NMR进行了结构表征，生物活性测试结果表明目标化合物对小麦赤霉病菌等没有抑制作用。 |
| 关 键 词： | 农药学；α-亚氨基膦酸酯；合成；生物活性 |
| Title： | Synthesis and diological activity of α-iminophosphonates derivatives |
| Author： | CHEN Zhuo, GU Lijun, GAO Xingwen, LU Ping, XU Yingshu, SONG Baoan, JIN Linhong |
| Organization： | Research and Development Center of Fine Chemicals, Guizhou University, Key Laboratory of Green Pesticide and Bioengineering, Ministry of Education, Key Laboratory of Fine chemicals, Guizhou Prouince |
| Abstract： | Aminophosphonic acid and their derivates as phosphorus analogues of natural amino acids have been noteworthy at home and abroad nowadays. They play more and more important roles in organic chemistry, medicine and agrochemicals. In this paper, nine novel α-iminophosphonate compounds were designed and synthesized in 49.2%～60.6% yields for benzoyl chloride or fluoro benzoyl chloride as starting material. The structure of the substances was confirmed by elemental analysis, IR and 1H NMR. The bioassay results showed that the new compounds had no good antifungal activity against growth of crop pathogenic fungi. |
| Key words： | pesticide science; α-iminophophonate; synthesis; biological activity |
| 发表期数： | 2008年8月第8期 |
| 引用格式： | 陈卓，谷利军，高兴文，等. α-亚氨基膦酸酯的合成与生物活性研究[J]. 中国科技论文在线精品论文，2008，1（8）：879-886. |
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