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卡马西平-糖精共晶的制备与分析研究

发表时间:2011-04-15  浏览量:1665  下载量:489
全部作者: 李润妍,丛海峰,毛会林,龚俊波
作者单位: 天津大学化工学院
摘 要: 通过不同的结晶方法制备了卡马西平-糖精的共晶,通过单晶衍射、X-射线粉末衍射(powder X-ray diffraction, PXRD)、差热扫描量热仪(differential scanning calorimeter, DSC)、红外光谱分析(fourier transform infrared spectroscopy, FT-IR)对其进行定性分析。通过实验考察不同溶剂对共晶和其组分晶习的影响,并运用Materials Studio软件对共晶的晶习进行模拟。结果发现:不同的溶剂对卡马西平和糖精的晶习有一定的影响,但对于卡马西平-糖精共晶的晶习影响不大;用软件模拟预测的晶习与单晶的晶习趋势基本一致。
关 键 词: 制药工程;卡马西平-糖精共晶;制备;模拟;晶习
Title: Study on preparation and analysis of carbamazepine-saccharin cocrystal
Author: LI Runyan, CONG Haifeng, MAO Huilin, GONG Junbo
Organization: School of Chemical Engineering and Technology, Tianjin University
Abstract: Carbamazepine-saccharin (CBZ-SAC) cocrystal was prepared using different crystallization technologies, and characterized by single crystal diffraction, powder X-ray diffraction(PXRD), differential scanning calorimeter (DSC)and Fourier transform infrared spectrometry (FT-IR). Crystal habits of CBZ, SAC and CBZ-SAC in different solvents were investigated, the cocrystal habit was simulated by the Materials Studio software. It is showed that solvents affected CBZ and SAC crystal habits than that of CBZ-SAC, the simulated cocrystal habit fitted well with the experimental one.
Key words: pharmaceutical engineering; carbamazepine-saccharin cocrystal; preparation; simulation; crystal habit
发表期数: 2011年4月第7期
引用格式: 李润妍,丛海峰,毛会林,等. 卡马西平-糖精共晶的制备与分析研究[J]. 中国科技论文在线精品论文,2011,4(7):667-672.
 
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