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触角式环糊精手性固定相的制备及表征

发表时间:2012-05-15  浏览量:1112  下载量:532
全部作者: 汪全义,朱卫霞,崔艳南,谢爽,宋航,杜开峰
作者单位: 四川大学化学工程学院
摘 要: 旨在制备一种新型触角式环糊精(cyclodextrin,CD)手性固定相(chiral stationary phase, CSP)(β-CD-PVA-SiO2),以增加环糊精手性配基在硅胶载体上的接枝量。以γ-氨丙基三甲氧基硅烷和戊二醛为偶联剂,通过表面接枝技术,将聚合长链聚乙烯醇(polyvingl alcohol, PVA)接枝在硅胶表面,形成多羟基硅胶衍生物。最后,通过γ-缩水甘油丙基三甲氧基硅烷的偶联作用将β-环糊精修饰在PVA-SiO2表面,形成β-CD-PVA-SiO2. 采用傅里叶变换红外光谱(Fourier transform-infrared spectroscopy,FT-IR)、热重分析(thermogravimetric analysis,TGA)、Dubois M法及莫氏(Molisch)颜色试剂对手性固定相进行表征。结果表明:环糊精成功地接枝在PVA-SiO2上且接枝量是传统固定相的3倍。
关 键 词: 材料物理与化学;手性固定相;触角式;环糊精
Title: Preparation and characterization of new tentacle-type chiral stationary phase of β-CD
Author: WANG Quanyi, ZHU Weixia, CUI Yannan, XIE Shuang, SONG Hang, DU Kaifeng
Organization: College of Chemical Engineering, Sichuan University
Abstract: To add the amount of β-CD on SiO2, the new tentacle-type β-CD chiral stationary phase (CSP) was prepared. In the study, choosing γ-aminopropyltrimethoxysilane as the coupling agent, PVA was grafted on the surface of SiO2 by using a surface grafting technique, to get more OH on the SiO2 derivant. Finally, β-CD was used to modify the PVA-SiO2 by coupling action of γ-glycidoxypropyltrimethoxysilane, to get β-CD-PVA-SiO2. Using Fourier transform-infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), Dubois M method and Molisch regents were employed to characterize the properties of the CSPs. The experimental results showed that β-CD was successfully grafted on PVA-SiO2 and the amount was 3 times of conventional CPS.
Key words: material physics and chemistry; chiral stationary phase; tentacle-type; cyclodextrin
发表期数: 2012年5月第9期
引用格式: 汪全义,朱卫霞,崔艳南,等. 触角式环糊精手性固定相的制备及表征[J]. 中国科技论文在线精品论文,2012,5(9):825-829.
 
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