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从济源冬凌草中分离得到的3个二萜类化合物
发表时间：2014-06-15 浏览量：2032 下载量：562
| 全部作者： | 王书波，付婷，王繁华，侯瑞娟，李惠举，可钰，刘宏民 |
| 作者单位： | 郑州大学药学院 |
| 摘 要： | 目的：研究济源冬凌草中的化学成分。方法：利用柱层析方法分离纯化济源冬凌草乙醇提取液，获得单一结构的化合物，根据质谱、核磁共振等波谱数据确定其结构并初步测试其细胞毒性。结果：从济源冬凌草中提取出了3个二萜类化合物。结论：这3个二萜类化合物为首次从济源冬凌草中分离得到，其中化合物1 和3对人食管癌Eca109细胞具有一定的细胞毒性。 |
| 关 键 词： | 药物化学；济源冬凌草；化学成分；结构鉴定；二萜 |
| Title： | Isolation and identification of three diterpenoid compounds extracted from Jiyuan rubescens |
| Author： | WANG Shubo, FU Ting, WANG Fanhua, HOU Ruijuan, LI Huiju, KE Yu, LIU Hongmin |
| Organization： | School of Pharmaceutical Science, Zhengzhou University |
| Abstract： | Objective: To study the chemical constituents of Jiyuan rubescens. Methods: The chemical constituents were isolated by method of chromatographic isolation, and their structures were elucidated by the analysis of spectral data and physiochemical properties. Furthermore, their cell cytotoxicity was also tested. Results: Three diterpenoid compounds were isolated from Jiyuan rubescens. Conclusion: These three compounds were firstly isolated from Jiyuan rubescens, in which compounds 1 and 3 showed certain cytotoxicity on human esophageal carcinoma Eca109 cells. |
| Key words： | medicinal chemistry; Jiyuan rubescens; chemical composition; structure identification; diterpenoid |
| 发表期数： | 2014年6月第11期 |
| 引用格式： | 王书波，付婷，王繁华，等. 从济源冬凌草中分离得到的3个二萜类化合物[J]. 中国科技论文在线精品论文，2014，7（11）：1097-1101. |
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