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caveolin-1调控干细胞作用的研究进展

发表时间:2016-02-15  浏览量:2275  下载量:773
全部作者: 白琳
作者单位: 中国医学科学院/北京协和医学院医学实验动物研究所,卫生部人类比较医学重点实验室
摘 要: caveolin-1是细胞膜结构胞膜窖的重要组成蛋白,其参与胆固醇的运输、细胞信号的传导、细胞增殖、肿瘤生成、细胞内吞等生物学过程。本文总结了caveolin-1在胚胎干细胞、造血干细胞、神经干细胞、间充质干细胞等细胞增殖和分化的调节作用及其相关的下游信号通路。综述了caveolin-1在不同干细胞中的调节作用对干细胞治疗和再生医学发挥重要作用。
关 键 词: 细胞生物学;caveolin-1;综述;干细胞;增殖;分化
Title: Research progress on the role of caveolin-1 in stem cells function
Author: BAI Lin
Organization: Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College
Abstract: Caveolin-1 is a protein in the plasma membrane invaginations. caveolin-1 is involved in the regulation of many cellular processes, including cholesterol regulation, cell signaling, cell growth, tumor and endocytosis etc. In this paper, we summarized the role of caveolin-1 in the regulation of embryonic stem cells, hemopoietic stem cells, neural stem cells and mesenchymal stem cells proliferation and differentiation. The regulatory effect of caveolin-1 on stem cells in the treatment of stem cells and regenerative medicine was reviewed.
Key words: cell biology; caveolin-1; review; stem cell; proliferation; differentiation
发表期数: 2016年2月第3期
引用格式: 白琳. caveolin-1调控干细胞作用的研究进展[J]. 中国科技论文在线精品论文,2016,9(3):200-204.
 
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