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ERK1/2信号通路在脑缺血再灌注中作用机制的研究进展

发表时间:2016-12-15  浏览量:1426  下载量:411
全部作者: 郭凯航,王嘉麟,邢佳,贺立娟,朱晓晨,郭蓉娟
作者单位: 北京中医药大学东方医院康复科
摘 要: 缺血性脑血管病导致脑组织损伤的机制及信号转导途径是近年来的研究热点,其中ERK1/2信号通路是一条经典且重要的途径。目前的研究表明该通路参与了脑缺血损伤的神经细胞凋亡过程,而具体的作用机制尚存在争议。本文将近三年有关脑缺血再灌注与ERK1/2信号通路的相关性研究成果及文献进行了综述,进而对今后的研究思路进行建议。
关 键 词: 神经病学;脑缺血再灌注;综述;ERK1/2信号通路
Title: Research progress on the effect and mechanism of ERK1/2 signaling pathway in cerebral ischemia reperfusion
Author: GUO Kaihang, WANG Jialin, XING Jia, HE Lijuan, ZHU Xiaochen, GUO Rongjuan
Organization: Physiatry Department, Dongfang Hospital of Beijing University of Chinese Medicine
Abstract: The mechanism and signal transduction pathway of brain tissue injury caused by ischemic cerebrovascular disease have become a hot spot of research for several years. As a classic and important signaling pathway, current studies show that ERK1/2 signaling pathway participates in the process of neuronal cell apoptosis after cerebral ischemic injury, but the specific effects and mechanisms are still controversial. In this paper, we present comprehensively the research achievements and literatures about the correlation between cerebral ischemic injury and ERK1/2 signaling pathway, and give some advice for the future study.
Key words: neurology; cerebral ischemia reperfusion; review; ERK1/2 signaling pathway
发表期数: 2016年12月第23期
引用格式: 郭凯航,王嘉麟,邢佳,等. ERK1/2信号通路在脑缺血再灌注中作用机制的研究进展[J]. 中国科技论文在线精品论文,2016,9(23):2388-2395.
 
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