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组织工程骨血管化研究进展

发表时间:2017-06-15  浏览量:182  下载量:19
全部作者: 特列克•坎扎勒,叶尔扎提•哈加合曼,金格勒
作者单位: 新疆医科大学第一附属医院骨科中心
摘 要: 构建组织工程骨快速血管化是发挥其骨缺损修复的主要瓶颈和关键因素。骨组织工程的发展为大段骨缺损的修复提供了新的途径,众多的动物实验研究和逐渐兴起的临床应用研究已充分显示出其巨大的应用前景。然而,组织工程骨细胞支架复合物在植入体内后,尤其是植入血供不佳的受区时,因不能及时地与机体建立起血供连接,使成骨效果不稳定。近年来,组织工程骨的血管化已成为构建大段组织工程骨的一个关键因素。研究回顾血管化策略的进展提示,利用骨组织工程培养的人工骨不仅可以修复大面积骨缺损,而且可以按需塑形并大量制备,是一种理想的骨修复材料,而血管化组织工程骨将会更好地应用于临床骨缺损患者的治疗中。
关 键 词: 外科学;血管化;综述;组织工程骨;细胞因子;骨缺损
Title: Research advance of tissue-engineered bone with vascularization
Author: TELIEKE Kanzhale, YEERZHATI Hajiaheman, JIN Gele
Organization: Orthopedic Centre, The First Affiliated Hospital of Xinjiang Medical University
Abstract: Construction of tissue-engineering bone (TEB) rapid vascularization is the main bottleneck and key factor of bone defect repair. The development of bone tissue engineering provides a promising way to repair large segments of bone defects. It has already showed tremendous potential for application on the basis of numerous animal experiments and rising clinical studies. However, osteogenesis of the TEB grafts may be unstable after TEB constructs implanted in vivo, especially in sites with poor blood supply for it cannot establish a blood supply connection with engine body in time. In recent years, the vascularization of TEB plays a vital role in generating large segments of bone grafts. In this paper, the review of the progress of the vascularization strategy suggests that the artificial bones cultured by bone tissue engineering can not only repair large areas of bone defects, but also be shaped and large prepared, and it is an ideal kind of bone repair materials. Vascularization TEB will be better applied in the treatment of patients with clinical bone defects.
Key words: surgery; vascularization; review; tissue-engineered bone; cytokines; bone defect
发表期数: 2017年6月第11期
引用格式: 特列克•坎扎勒,叶尔扎提•哈加合曼,金格勒. 组织工程骨血管化研究进展[J]. 中国科技论文在线精品论文,2017,10(11):1189-1195.
 
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