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经颅磁电脑病治疗仪治疗阿尔茨海默病的临床研究

发表时间:2017-06-15  浏览量:78  下载量:25
全部作者: 唐强,邹伟,孙作东,邢艳丽,于学平,李康,孙五一,王文华,刘波,张立,戴晓红,侯艳
作者单位: 黑龙江中医药大学附属第二医院康复科;黑龙江中医药大学附属第一医院康复科;黑龙江省亚欧脑科学研究院;哈尔滨医科大学公共卫生学院;哈尔滨奥博医疗器械有限公司
摘 要: 目的:评价经颅磁电(transcranial magnetoelectric,TME)脑病治疗仪(商品名:奥博阿尔茨海默治疗仪)治疗轻、中度阿尔茨海默病(Alzheimer’s disease,AD)的有效性及安全性。方法:对80例轻、中度AD患者[Hachinski缺血量表评分≤4分,临床痴呆评价(clinical dementia rating,CDR)=1.0或CDR=2.0]进行双中心、随机、双盲、平行、安慰剂对照8周临床试验,其中治疗组和对照组各40例。所有入选病例均给予正规的内科基础治疗和规范化护理,治疗组使用TME脑病治疗仪进行治疗,对照组使用安慰TME脑病治疗仪进行模拟治疗。结果:治疗8周时,治疗组较对照组的简易精神状态评价(mini-mental state examination,MMSE)、阿尔茨海默病评定量表(Alzheimer’s disease assessment scale,ADAS)和日常生活能力(activities of daily living,ADL)评价分数显著改善(组间差异P依次<0.001、0.000 1、0.05)。且治疗4周时,MMSE和ADAS分数已有提高(组间差异P依次<0.05、0.01)。两组均无不良反应。结论:TME脑病治疗仪治疗轻、中度AD具有治疗效果,对患者的精神状态、认知行为和日常生活自理能力有较好的改善作用,且该治疗仪使用安全。
关 键 词: 康复医学;经颅磁电;阿尔茨海默病;电压门控钙离子通道;最佳靶点;脑细胞激活论
Title: Clinical study on transcranial magnetoelectric encephalopathy treatment instrument for Alzheimer’s disease
Author: TANG Qiang, ZOU Wei, SUN Zuodong, XING Yanli, YU Xueping, LI Kang, SUN Wuyi, WANG Wenhua, LIU Bo, ZHANG Li, DAI Xiaohong, HOU Yan
Organization: Department of Rehabilitation, Second Affiliated Hospital, Heilongjiang University of Chinese Medicine; Department of Rehabilitation, First Affiliated Hospital, Heilongjiang University of Chinese Medicine; Ya’ou Brain Science Institute of Heilongjiang Province; Public Health College of Harbin Medical University; Harbin Aobo Medical Apparatus Co., Ltd.
Abstract: Objective: To evaluate the treatment efficacy and safety for transcranial magnetoelectric (TME) encephalopathy treatment instrument (brand name: AOBO Alzheimer’s Treatment Instrument) for mild to moderate Alzheimer’s disease (AD). Methods: 80 patients with mild to moderate AD [Hachinski ischemia score≤4 cent, clinical dementia rating (CDR)=1.0 or CDR=2.0] were given double center, randomized, double blind, parallel and placebo controlled, clinical trial for 8 weeks, including treatment group and control group, each of 40 cases. All the patients were given regular basic medical treatment and standardized nursing care. The patients of treatment group were treated with TME encephalopathy treatment instrument, while the patients of control group were simulated with TME encephalopathy treatment instrument. Results: After treated for 8 weeks, compared with the control group, the treatment group’s scores of mini-mental state examination (MMSE), Alzheimer’s disease assessment scale (ADAS) and activities of daily living (ADL) improved significantly (differences between groups are P<0.001, 0.000 1, 0.05, respectively). After treated for 4 weeks, the scores of MMSE and ADAS are improved (differences between groups are P<0.05, 0.01, respectively). There was no adverse reaction in the two groups. Conclusion: TME encephalopathy treatment instrument has good therapeutic effect on mild to moderate AD patients, which can improve the mental state, cognitive behavior and self-care ability of daily life with safety.
Key words: rehabilitation medicine; transcranial magnetoelectric; Alzheimer’s disease; voltage-gated Ca2+ channels; best target; theory of brain cell activation
发表期数: 2017年6月第11期
引用格式: 唐强,邹伟,孙作东,等. 经颅磁电脑病治疗仪治疗阿尔茨海默病的临床研究[J]. 中国科技论文在线精品论文,2017,10(11):1216-1222.
 
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