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茶多酚复方口服液改善辐射后小鼠血象、延长其生存期的实验研究

发表时间:2017-06-15  浏览量:51  下载量:18
全部作者: 曾亚楠,张蒙,来枫,程慧颖,陈秋,崔凤梅
作者单位: 苏州大学医学部放射医学与防护学院
摘 要: 目的:观察茶多酚复方口服液对辐射后小鼠血常规检测指标和生存期的影响。方法:小鼠随机分为4组,正常对照组、辐射对照组、茶多酚复方口服液低浓度组和高浓度组。辐射对照组及茶多酚复方口服液实验组小鼠各接受1次4 Gy钴60 γ射线照射,同时茶多酚复方口服液实验组小鼠辐射后用茶多酚复方口服液灌胃,连续7 d. 然后分别于照射后7,14,21,28 d取血检测白细胞(white blood cells,WBC)、淋巴细胞(lymphocytes,LYM)、中性粒细胞(neutrophils,NEU)、红细胞(red blood cells,RBC)、血小板(platelet,PLT)、单核细胞(monocytes,MON)、平均红细胞体积(mean corpuscular volume,MCV)、平均血红蛋白量(mean corpuscular haemoglobin,MCH)、平均红细胞血红蛋白浓度(mean corpuscular hemoglobin concentration,MCHC)、平均血小板体积(mean platelet volume,MPV)、血小板压积(plateletcrit,PCT)。另一批小鼠接受1次8 Gy钴60 γ射线照射,并每天观察生存情况。结果:茶多酚复方口服液可以提高小鼠外周血WBC、LYM、NEU和PLT的数量,但对RBC无影响,对MON、MCV、MCHC、PCT具有一定的影响,而对MCH、MPV无影响,并显著延长小鼠的生存期。结论:茶多酚复方口服液具有一定抗辐射损伤的作用,对辐射后骨髓造血功能有一定的保护作用,同时能够延长小鼠的生存期。
关 键 词: 放射医学;茶多酚复方口服液;钴60 γ射线;血常规检测
Title: Experimental study on tea polyphenol compound oral liquid improving hematopoiesis and prolonging survival of irradiated mice
Author: ZENG Yanan, ZHANG Meng, LAI Feng, CHENG Huiying, CHEN Qiu, CUI Fengmei
Organization: School of Radiation Medicine and Protection, Medical College of Soochow University
Abstract: Objective: To investigate the influence of tea polyphenol compound oral liquid on the routine blood test index and survival in mice after irradiation. Methods: The mice were randomly divided into 4 groups i.e. the normal control group, irradiation control group, tea polyphenol compound oral liquid low concentration group and high concentration group. The irradiation control and tea poly phenol compound oral liquid experimental groups were exposed 4 Gy 60Co γ-ray irradiation, and the mice of tea poly phenol compound oral liquid experimental groups were given tea polyphenol compound oral liquid for 7 d straight after radiation. The blood of the mice were obtained 7, 14, 21, 28 d after radiation, in which the content of white blood cells (WBC), lymphocytes (LYM), neutrophils (NEU), red blood cells (RBC), platelet (PLT), monocytes (MON), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean platelet volume (MPV) and plateletcrit (PCT) were detected. Meawhile, another part of mice received 8 Gy 60Co γ-ray irradiation and their survival condition was analyzed. Results: Tea polyphenol compound oral liquid can improve the number of peripheral WBC, LYM, NEU and PCT in mice after radiation, while it has no influence on RBC. Meanwhile, Tea polyphenol compound oral liquid has certain influence on the contents of MON, MCV, MCHC, and PCT in mice, but it has no influence on MCH and MPV, and it can also prolong survival time in mice after irradiation. Conclusion: Tea polyphenol compound oral liquid shows certain anti-radiation effect through protecting bone marrow hematopoietic function and it can prolong survival time as well in mice after γ-ray irradiation.
Key words: radioactive medicine; tea polyphenol compound oral liquid; 60Co γ-ray; routine blood test
发表期数: 2017年6月第11期
引用格式: 曾亚楠,张蒙,来枫,等. 茶多酚复方口服液改善辐射后小鼠血象、延长其生存期的实验研究[J]. 中国科技论文在线精品论文,2017,10(11):1268-1275.
 
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