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HOXB7在肿瘤中作用的研究进展

发表时间:2017-08-15  浏览量:47  下载量:12
全部作者: 蔡华勇,孔祥俊,朱涛
作者单位: 中国科学技术大学生命科学学院
摘 要: 同源域蛋白(homeodomain protein)HOXB7在癌症中扮演了重要的角色。分子水平和细胞水平的研究均已证明HOXB7是人体中一个主要的调控基因,能够影响许多靶蛋白的表达水平,导致很多促癌信号通路的激活。本研究从现象和机理上总结了HOXB7在乳腺癌中的异常表达与乳腺癌内分泌疗法耐药性的关系,同时也涉及HOXB7在其他癌症中的研究进展。HOXB7在肿瘤中的表达与肿瘤的临床恶性程度和不良预后相关。在缺少有效治疗手段的癌症中,如具有他莫昔芬耐药性的乳腺癌和黑色素瘤,特异性抑制HOXB7可能成为有效的治疗手段。对HOXB7在癌症中的机理研究,正在提供更多的治疗靶点。HOXB7作为靶点的临床药物的开发和作为临床诊断和预后的标志性分子的作用,表明了HOXB7在肿瘤治疗中的重要性。
关 键 词: 分子生物学;HOXB7;综述;同源域蛋白;同源异型盒基因
Title: Review of HOXB7 research progress in tumor
Author: CAI Huayong, KONG Xiangjun, ZHU Tao
Organization: School of Life Sciences, University of Science and Technology of China
Abstract: Numerous studies have established a critical role for homeodomain protein HOXB7 in cancer. HOXB7 is a master regulatory gene on molecular level and cell level in human genome that could orchestrate variety of oncogenic pathways and have influence on many downstream target genes’ expression. We mainly compile the relationship between abnormal expression of HOXB7 in breast cancer and its endocrine medicine resistance based on phenomenal and mechanism, as well as the development of HOXB7 in other cancers. It has also shown that HOXB7 is correlated with advanced clinical stages of tumors and poor progonosis of patients with malignant tumors other than breast cancer. Specific inhibition of HOXB7 could be an effective therapeutic tool in lacking effective treatment of cancers, for example, breast cancer with Tamoxifen resistance and melanoma. Researches on functional mechanism of HOXB7 in cancer are providing more therapeutic targets. Also, HOXB7 is emerging as potent potential target for drug design and as informative diagnosis and prognosis biomarkers, which shows the importance of HOXB7 in tumor therapy.
Key words: molecular biology; HOXB7; review; homeodomain protein; homeobox gene
发表期数: 2017年8月第15期
引用格式: 蔡华勇,孔祥俊,朱涛. HOXB7在肿瘤中作用的研究进展[J]. 中国科技论文在线精品论文,2017,10(15):1672-1678.
 
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