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柠檬醛在日本鳗鲡体内的药代动力学

发表时间:2017-08-15  浏览量:78  下载量:25
全部作者: 岑万,张倩,林岗
作者单位: 福建省海洋生物医药与制品产业化开发技术公共服务平台;福建师范大学生命科学学院
摘 要: 采用超高效液相色谱(ultra performance liquid chromatography,UPLC)法研究在温度25~27℃、pH值6.8~7.0条件下,以3.556 mg/L浓度的柠檬醛药浴日本鳗鲡24 h,在不同时间段测定其体内各组织中柠檬醛药物残留量,利用DAS软件分析其消除规律。结果表明,柠檬醛在日本鳗鲡鳃、肌肉、肝脏、血浆中的房室模型均为一室模型,肾脏中为二室模型。柠檬醛在日本鳗鲡肌肉、肝脏、肾脏、鳃和血浆中的药代动力学参数如下:达峰浓度(Cmax)分别为0.014,0.011,0.009,0.004,0.049 mg/L;达峰时间(Tmax)分别为24,48,3,6,6 h;表观分布容积(Vz/F)分别为0.561,1.191,1.093,3.342,213.294 L/kg;药时曲线下面积(AUC0~∞)分别为1.924,3.454,7.148,0.404,6.750 mg/(L•h);平均滞留时间(MRT0~∞)分别为150.596,554.578,1 200.69,196.608,199.928 h;消除半衰期(t1/2z)分别为105.131,400.889,761.328,131.749,140.295 h. 药代动力学参数表明,柠檬醛在日本鳗鲡体内的代谢一部分经鳃直接排出,另一部分通过血浆运送至肌肉、肝脏等其他组织,再转至肝脏并蓄积,代谢产物经肾脏排泄。
关 键 词: 水产保护学;超高效液相色谱;柠檬醛;日本鳗鲡;药物残留;药代动力学参数
Title: Pharmacokinetic of citral in vivo of Anguilla japonica
Author: CEN Wan, ZHANG Qian, LIN Gang
Organization: Fujian Public Service Platform for Industrialization Development Technology of Marine Biological Medicine and Product of State Oceanic Administration;College of Life Sciences, Fujian Normal University
Abstract: An ultra performance liquid chromatography (UPLC) method was applied to determine the residues of citral in plasma and tissues of Anguilla japonica exposed to citral at a concentration of 3.556 mg/L for 24 h (25-27℃, pH=6.8-7.0) at different time periods. The distribution and elimination regulalion of citral was analyzed by DAS software. The results showed that the concentration-time data of citral were described as one-compartment model in the gill, muscle, liver and plasma, and as two-compartment model in the kidney. The main pharmacokinetic parameters in the muscle, liver, kidney, gill and plasma were obtained as follows: Cmax=0.014, 0.011, 0.009, 0.004, 0.049 mg/L; Tmax=24, 48, 3, 6, 6 h; Vz/F=0.561, 1.191, 1.093, 3.342, 213.294 L/kg; AUC0~∞=1.924, 3.454, 7.148, 0.404, 6.750 mg/(L•h); MRT0~∞= 150.596, 554.578, 1 200.69, 196.608, 199.928 h; t1/2z=105.31, 400.889, 761.328, 131.749, 140.295 h. The pharmacokinetic parameters showed that some of the metabolic pathways of citral in Anguilla japonica were eliminated directly from the gill, others were transported to different tissues (including the muscle) through the plasma, then moved and cumulated into the liver, finally excreted by the kidney.
Key words: fishery protection; ultra performance liquid chromatography; citral; Anguilla japonica; drug residue; pharmacokinetic parameters
发表期数: 2017年8月第15期
引用格式: 岑万,张倩,林岗. 柠檬醛在日本鳗鲡体内的药代动力学[J]. 中国科技论文在线精品论文,2017,10(15):1744-1752.
 
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