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可见光介导的DNA兼容的烯烃氧化研究

发表时间:2024-01-16  浏览量:144  下载量:38
全部作者: 王镱婷,方贤富,李杨峰,李亦舟
作者单位: 重庆大学药学院
摘 要: 本文研究了一种DNA兼容的化学方法,将DNA烯烃偶联物氧化为DNA醛/酮偶联物。本文通过可见光和光敏剂介导下将DNA烯烃偶联物转化为DNA醛/酮偶联物,该方法具有条件温和、与水兼容等特点。其研究意义有以下两点:1)为DNA兼容反应提供更丰富的DNA醛/酮偶联底物;2)为DNA编码分子库(DNA-encoded library,DEL)领域官能团转化反应提供化学策略,增加了DNA编码分子库的结构多样性。
关 键 词: 化学其他学科;可见光介导;烯烃氧化反应;DNA兼容反应
Title: Visible light-mediated DNA-compatible olefin oxidation
Author: WANG Yiting, FANG Xianfu, LI Yangfeng, LI Yizhou
Organization: School of Pharmaceutical Sciences, Chongqing University
Abstract: This paper developed a DNA compatible chemical method for the oxidation of DNA-conjugate olefins to DNA-conjugate aldehydes/ketones. This paper converted DNA-conjugate olefins into DNA-conjugate aldehydes/ketones mediated by visible light and photosensitizers, which is mild and water-compatible. The significance of this paper is as follows: 1) provide more abundant DNA-conjugate aldehydes/ketones for DNA compatible reactions; 2) provide a chemical strategy for functional group transformation reactions in the DNA-encoded library (DEL), which increases the structural diversity of DNA-encoded library.
Key words: other subjects of chemistry; visible light-mediated; alkene oxidation reaction; DNA compatible reaction
发表期数: 2023年12月第4期
引用格式: 王镱婷,方贤富,李杨峰,等. 可见光介导的DNA兼容的烯烃氧化研究[J]. 中国科技论文在线精品论文,2023,16(4):547-552.
 
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