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雷公藤多甙抑制大鼠心脏移植排斥反应的研究
发表时间：2010-12-15 浏览量：1831 下载量：517
| 全部作者： | 周云，闫志国，杨绍军，杨达宽 |
| 作者单位： | 昆明医学院第二附属医院胸心外科 |
| 摘 要： | 目的：研究雷公藤多甙对大鼠心脏移植排斥反应的抑制作用。方法：以SD大鼠为供体，Wistar大鼠为受体，采用肾静脉套管法建立大鼠腹部异位心脏移植模型，治疗组术前3 d管饲给予雷公藤多甙30 mg·kg - 1·d-1. 观察移植心脏搏动强度、存活时间、排异反应分级和受体鼠外周血IL-2水平。结果：治疗组移植心脏搏动强度、搏动时间优于对照组，排异反应程度减轻，受体鼠外周血IL-2水平明显低于对照组。结论：应用雷公藤多甙能够抑制大鼠心脏移植排斥反应。 |
| 关 键 词： | 医学实验动物学；雷公藤多甙；心脏移植；免疫抑制 |
| Title： | Study on immunosuppression of Glucosida Tripterygii in heart-transplanted rats |
| Author： | ZHOU Yun, YAN Zhiguo, YANG Shaojun, YANG Dakuan |
| Organization： | Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Kunming Medical College |
| Abstract： | Objective: To study the immunosuppression of Glucosida Tripterygii in heart-transplanted rats. Methods: Male SD rats served as donors and Wistar as recipients, heart transplantation was performed by renal vein cuff technique. Thirty six recipients were divided into two groups at random: control group and Glucosida Tripterygii treated group (30 mg·kg-1·d-1 ). Transplanted heart beating intensity and beating time were observed. The level of IL-2 in recipients’ serum was measured by ELISA method. Transplanted heart were collected and examined by HE stain, when they did not beat. Results: In Glucosida Tripterygii treated group, transplanted heart beating intensity was stronger, beating time was longer, the concentration of IL-2 in serum was lower, and rejection was obviously mild than them in control group. Conclusion: Glucosida Tripterygii can suppress the rejection in heart-transplanted rats. |
| Key words： | medicine laboratory animal science; Glucosida Tripterygii; heart transplantation; immunosuppression |
| 发表期数： | 2010年12月第23期 |
| 引用格式： | 周云，闫志国，杨绍军，等. 雷公藤多甙抑制大鼠心脏移植排斥反应的研究[J]. 中国科技论文在线精品论文，2010，3（23）：2389-2391. |
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