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具有抗菌性能的羧甲基壳聚糖/磺胺嘧啶银复合膜的制备与表征
发表时间：2012-05-15 浏览量：1420 下载量：391
| 全部作者： | 张令辉，张灵敏，王秋兰，蔡继业，娄翠 |
| 作者单位： | 暨南大学生命科学技术学院 |
| 摘 要： | 首次通过羧甲基壳聚糖（carboxymethyl chitosan，CMC）水溶液与磺胺嘧啶银（silver sulfadiazine，SSD）共混的方式制备具有抗菌性能的水溶性羧甲基壳聚糖/磺胺嘧啶银（CMC/SSD）复合膜。复合膜的结构及性能分别由原子力显微镜（atomic force microscopy，AFM）、傅里叶变换红外光谱（Fourier transformed infrared spectroscopy，FTIR），X射线衍射（X-ray diffraction，XRD）等进行表征。AFM形貌图显示：CMC/SSD膜表面的平均粗糙度比单纯CMC膜的大；CMC/SSD膜的FTIR及XRD图显示，SSD在CMC中能稳定存在，两者共存良好。CMC/SSD膜液对大肠杆菌8099及金黄色葡萄球菌ATCC 6538的抑菌率随浓度的增加而增加。 |
| 关 键 词： | 材料科学基础学科；羧甲基壳聚糖；磺胺嘧啶银；表面形貌；傅里叶变换红外光谱；X射线衍谢；抗菌 |
| Title： | Preparation and characterization of antibacterial CMC/SSD composite membranes |
| Author： | ZHANG Linghui, ZHANG Lingmin, WANG Qiulan, CAI Jiye, LOU Cui |
| Organization： | College of Life Science and Technology, Jinan University |
| Abstract： | A novel composite membrane of carboxymethyl chitosan (CMC)/silver sulfadiazine (SSD) was prepared by mixing CMC water solution with SSD. The structure and the properties of the composite membranes were investigated by atomic force microscopy (AFM), Fourier transformed infrared spectroscopy (FTIR), X-ray diffraction (XRD) and so on. AFM images of the composite membrane showed that the average roughness of the composite membrane was larger than the membrane prepared by only CMC. The results of FTIR and XRD showed that SSD was stable in CMC and both of them could exist finely together. The inhibitory rates of solution of the composite membrane against Escherichia coli 8099 and Staphylococcus aureus ATCC 6538 increased with the increasing concentration of solution respectively. It’s a promising wound dressing. |
| Key words： | foundational subject in materials science; carboxymethyl chitosan; silver sulfadiazine; surface morphology; Fourier transformed infrared spectroscopy; X-ray diffraction; antibacterial property |
| 发表期数： | 2012年5月第9期 |
| 引用格式： | 张令辉，张灵敏，王秋兰，等. 具有抗菌性能的羧甲基壳聚糖/磺胺嘧啶银复合膜的制备与表征[J]. 中国科技论文在线精品论文，2012，5（9）：801-807. |
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