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乳腺癌中PR的表达及其与TNF-α相关性研究
发表时间：2012-06-15 浏览量：1513 下载量：683
| 全部作者： | 喻明霞 |
| 作者单位： | 武汉大学中南医院检验科&基因检测中心 |
| 摘 要： | 目的：研究乳腺癌中孕激素受体（progesterone receptor，PR）的表达及其与肿瘤坏死因子- α（tumor necrosis factor- α， TNF- α）的相关性。方法：采用免疫组织化学（strept avidin- biotin complex，SABC）法检测112例原发性乳腺癌组织中PR，TNF- α的表达，分析PR与乳腺癌临床病理特征的关系以及PR和TNF- α的相关性。结果：1） 乳腺癌中PR的阳性表达率为23.21%（26/112）；2） PR在乳腺癌中的表达与TNM分期、年龄、初潮年龄、是否绝经、孕次、产次、肿瘤家族史均无相关性（P＞0.05）；3） PR与TNF- α在乳腺癌中的表达有显著正相关性（P<0.05）。结论：PR与乳腺癌多项临床病理特征无显著相关性，与TNF- α在乳腺癌中的表达显著正相关，具体机制有待进一步研究。 |
| 关 键 词： | 实验诊断学；孕激素受体；肿瘤坏死因子- α；乳腺癌 |
| Title： | Expressions of progesterone receptor and correlations with tumor necrosis factor-α in breast cancer |
| Author： | YU Mingxia |
| Organization： | Department of Clinical Laboratory & Genetic Testing Center, Zhongnan Hospital of Wuhan University |
| Abstract： | Objective: To determine the expression of progesterone receptor (PR) in breast cancer and its correlation with tumor necrosis factor- α (TNF- α). Methods: Strept avidin- biotin complex (SABC) method was used to detect the expressions of PR and TNF- α in 112 cases of primary breast cancer, and analyzed the association of PR with clinicopathological features of breast cancer and TNF- α. Results: 1) The positive expression rate of PR in breast cancer was 23.21%（26/112）. 2) There were no significant associations of PR with TNM staging, age, age of menarche, menopause, gravidity, parity and family history of cancer. 3) PR had a positive correlation with TNF- α in breast cancer (P<0.05). Conclusion: There was no significant association of PR with clinicopathological features of breast cancer. PR had a positive correlation with TNF- α in breast cancer, but the specific mechanism needs follow- up research. |
| Key words： | laboratory diagnostics; progesterone receptor; tumor necrosis factor- α; breast cancer |
| 发表期数： | 2012年6月第11期 |
| 引用格式： | 喻明霞. 乳腺癌中PR的表达及其与TNF-α相关性研究[J]. 中国科技论文在线精品论文，2012，5（11）：1054-1057. |
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