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低强度有氧运动对吸烟大鼠肝组织IL-1，IL-6和TNF-α含量影响研究
发表时间：2013-09-15 浏览量：1650 下载量：614
| 全部作者： | 文登台，钟救根，刘正，刘祥梅 |
| 作者单位： | 湖南师范大学体育学院 |
| 摘 要： | 目的：探讨低强度有氧运动与吸烟对肝组织促炎性细胞因子IL-1，IL-6，TNF-α含量水平的影响。方法：采用2×2析因设计，24只SD(Sprague-Dawley)大鼠随机分为控制对照组(C)、吸烟组(S)、运动组(E)和吸烟并运动组(ES)，每组6只(n=6)。S组被动吸烟、E组低强度有氧运动、ES组被动吸烟并低强度有氧运动，每周进行6 d，9周后检测各组大鼠肝组织IL-1，IL-6，TNF-α含量。结果：IL-1的含量，S组和ES组显著高于C组(P<0.05)；IL-6的含量，E组和ES组略高、S组略低于C组，但各组差异不显著（P>0.05）；TNF-α的含量，E组和ES组非常显著地高于C组（P<0.01）和S组（与E组相比P<0.05，与ES组相比P<0.01）；析因方差分析显示吸烟与低强度有氧运动两因素对肝组织IL-1，IL-6，TNF-α 含量水平无明显交互作用。结论：肝内IL-1含量异常上升和IL-6含量偏低与吸烟对肝脏的不良影响有关，低强度有氧运动的肝内促炎性因子变化有益于肝脏，但不能降低吸烟后肝IL-1含量上升的危害。 |
| 关 键 词： | 运动人体科学；低强度有氧运动；吸烟；肝脏；IL-1；IL-6；TNF-α |
| Title： | Research on the effect of the low intensity aerobic exercise and smoking on changing of IL-1, IL-6 and TNF-α content in rats’ liver tissue |
| Author： | WEN Dengtai, ZHONG Jiugen, LIU Zheng, LIU Xiangmei |
| Organization： | Physical Education College, Hunan Normal University |
| Abstract： | Objective: To research the effect of low intensity aerobic exercise and smoking on IL-1, IL-6, TNF-α content in liver tissue. Methods: 24 rats were randomly divided into C (rest control) group, S (smoking) group, E (exercise) group and ES (smoking+exercise) group. C group received no treatment; S group did not exercise but received passive smoking; E group took exercise, but not smoking; ES received passive smoking in the morning and took exercise in the afternoon, these took place 6 days per week and then had a rest on Sunday. The content of IL-1, IL-6 and TNF-α in liver tissue for every group of rats was tested after 9 weeks trained. Results: Compared with C group, IL-1 content in S group and ES group was significantly higher (P<0.05). Compared with C group, IL-6 content in E group and ES group was slightly higher, S group was slightly lower, but every group had no significant difference (P>0.05). Compared with C group, TNF-α content in E group and ES group was much significantly higher (P<0.01). Compared with S group, TNF-α content was significantly higher in ES group (P<0.01) and E group (P<0.05). Factorial analysis of variance showed that two factors smoking and low intensity aerobic exercise were no significant interactions on the liuer tissue IL-1, IL-6, TNF-α levels. Conclusion: The low intensity aerobic exercise can improve immune function, but its resistance to the effect of smoking on body damage is limited. Smoking may reduce the positive effect of the exercise. |
| Key words： | sports science of human body; low intensity aerobic exercise; smoking; liver; IL-1; IL-6; TNF-α |
| 发表期数： | 2013年9月第17期 |
| 引用格式： | 文登台，钟救根，刘正，等. 低强度有氧运动对吸烟大鼠肝组织IL-1，IL-6和TNF-α含量影响研究[J]. 中国科技论文在线精品论文，2013，6（17）：1671-1676. |
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