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“从肝论治，理气调神”针刺法治疗过敏性鼻炎的实验研究
发表时间：2013-12-15 浏览量：1536 下载量：384
| 全部作者： | 耿国燕，王朋，张佳佳，王蓬文，任映，赵吉平 |
| 作者单位： | 北京中医药大学针灸推拿学院；北京中医药大学东直门医院针灸科；北京中医药大学东直门医院中心实验室 |
| 摘 要： | 目的：探讨“从肝论治，理气调神”治疗过敏性鼻炎（allergic rhinitis，AR）的有效性及作用机制。方法：将40只豚鼠（雌雄各半）随机分为5组，分别为空白组（1）、模型组（2）、西药组（3）、常规组（4）及疏肝组（5），每组8只，雄鼠、雌鼠各4只，第2~5组以卵清蛋白(ovalbumin，OVA)复制AR模型。造模成功后次日开始干预：空白组、模型组不干预；西药组双侧鼻孔喷布地奈德喷雾剂，每次、每侧鼻孔1喷（64 μg）；常规组针刺双侧迎香（LI20）、肺俞穴(BL13)；疏肝针刺组针刺双侧迎香(LI20)、肺俞(BL13)、肝俞(BL18)、太冲穴(LR3)。肺俞(BL13)、肝俞(BL18)均不留针，余穴留针20 min. 第3~5组均每日干预1次，共干预15次，末次干预后给予10%（体积比）水合氯醛麻醉，然后在腹主动脉取血，经相应处理后，进行血清P物质（SP）（ELISA）测定及鼻黏膜嗜酸性粒细胞（eosinophils，EOS）计数。结果：西药疗法、常规针刺法及疏肝针刺法均能有效改善AR症状，抑制SP的释放，且3组疗效相当（P>0.05）；在改善EOS浸润方面，疏肝针刺法优于西药疗法和常规针刺法，差异显著（P<0.05）。结论：“从肝论治，理气调神”针法能通过抑制SP的释放，减轻EOS浸润释放，达到减轻AR症状、治疗AR的目的。 |
| 关 键 词： | 针灸学；针刺法；调神；过敏性鼻炎 |
| Title： | A randomized controlled experiment of soothing liver and regulating mind acupuncture |
| Author： | GENG Guoyan, WANG Peng, ZHANG Jiajia, WANG Pengwen, REN Ying, ZHAO Jiping |
| Organization： | School of Acupucture & Moxibustion and Tuina, Beijing Traditional Chinese Medicine University; Acupuncture and Moxibustion Department, Dongzhimen Hospital, Beijing Traditional Chinese Medicine University; Central Laboratory, Dongzhimen Hospital, Beijing Traditional Chinese Medicine University |
| Abstract： | Objective: To explore whether the method of soothing liver and regulating mind acupuncture is scientific and to explore the mechanism and targets of acupuncture treatment on allergic rhinitis (AR). Methods: 40 guinea pigs (20 males, 20 females) were randomly divided into 5 groups, which were blank group (1), model group (2), western medicine group (3), regular group (4), and soothing liver group (5). Each group included 8 guinea pigs (4 males, 4 females). Group 2-5 copied the AR model by ovalbumin (OVA). Interventions was carried after the 10th intranasal sensitization: blank group and model group were not intervened; western medicine group were sprayed budesonide sprays, each nostril sprayed 64 μg; regular group were acupunctured bilateral Yingxiang (LI20) and Feishu (BL13); soothing liver group were acupunctured bilateral Yingxiang (LI20), Feishu (BL13), Ganshu (BL18) and Taichong (LR3). Yingxiang (LI20), Feishu (BL13) and Ganshu (BL18) were without keeping the needles, the needle were kept for 20 minutes in others. Interventions for group 3-5 were performed once a day for 15 times. On the day of the 15th intervention, narcosis was used on the guinea pigs using 10% (v:v) chloral hydrate. Then blood from abdominal aorta was taken for the test of serum P (SP) (ELISA). And the mucous membranes of the nasal septum were taken for nasal eosinophils (EOS) counts. Results: Western medicine, regular acupuncture and soothing liver acupuncture therapy effectively decreased symptom score and inhibited the releasing of SP, and the difference between them was not significant (P>0.05). For decreasing nasal EOS cell infiltration, the soothing liver acupuncture therapy was better than western medicine and regular acupuncture therapy (P<0.05). Conclusion: Soothing liver and regulating mind acupuncture therapy may reduce EOS infiltration and inhibit the releasing of SP and decrease the symptoms of AR. |
| Key words： | science of acupuncture and moxibustion; acupuncture; regulating mind; allergic rhinitis |
| 发表期数： | 2013年12月第23期 |
| 引用格式： | 耿国燕，王朋，张佳佳，等. “从肝论治，理气调神”针刺法治疗过敏性鼻炎的实验研究[J]. 中国科技论文在线精品论文，2013，6（23）：2291-2297. |
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