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PEG修饰WS2纳米薄片用于活体光热治疗的研究
发表时间：2014-05-15 浏览量：2173 下载量：681
| 全部作者： | 程亮，刘晶晶，刘庄 |
| 作者单位： | 苏州大学功能纳米与软物质研究院，苏州纳米科技协同创新中心 |
| 摘 要： | 通过锂离子插层技术合成一种新的光热治疗(photothermal therapy, PTT)试剂WS2纳米薄片，应用在生物医学成像和肿瘤PTT中。利用巯基化学的方法，将聚乙二醇(polyethylene glycol, PEG)分子修饰在WS2纳米薄片的表面，使其具有更好的水溶性和生物相容性，并且在近红外（near-infrared, NIR）激光的照射下可以有效杀灭肿瘤，使过渡金属二硫化物(transition metal dichalcogenides, TMDC)材料在纳米生物医学领域中得到更广泛应用。 |
| 关 键 词： | 无机纳米材料；过渡金属二硫化物；毒性；生物成像；光热治疗 |
| Title： | PEG modified WS2 nanosheets for in vivo photothermal therapy |
| Author： | CHENG Liang, LIU Jingjing, LIU Zhuang |
| Organization： | Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University |
| Abstract： | In this work, a novel photothermal therapy (PTT) agent based on WS2 nanosheets was synthesized for bio-imaging and highly effective in vivo photothermal ablation of tumor PTT. Using the thiol chemistry method, the surface of WS2 nanosheets was coated with polyethylene glycol (PEG), which greatly improved the physiological stability and biocompability of those nanosheets. The PEGylated WS2 nanosheets (WS2-PEG) could serve as a powerful photothermal agent to effectively ablate cancer cells in vitro under near-infrared (NIR) laser irradiation. This work highlights the promise of using light-absorbing transition metal dichalcogenides (TMDC) nanosheets for cancer imaging and therapy. |
| Key words： | inorganic nanomaterial; transition-metal dichalcogenides; toxicity; bio-imaging; photothermal therapy |
| 发表期数： | 2014年5月第9期 |
| 引用格式： | 程亮，刘晶晶，刘庄. PEG修饰WS2纳米薄片用于活体光热治疗的研究[J]. 中国科技论文在线精品论文，2014，7（9）：844-851. |
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