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归附痛经颗粒对寒凝血瘀证模型大鼠血液流变性的影响
发表时间：2014-12-15 浏览量：1853 下载量：713
| 全部作者： | 于瑞红，曹蕾 |
| 作者单位： | 西安交通大学医学院 |
| 摘 要： | 目的：观察归附痛经颗粒对寒凝血瘀证模型大鼠血液流变性的影响。方法：制作急性寒凝血瘀证大鼠模型，用归附痛经颗粒灌胃1周，取血检测全血黏度和还原黏度、红细胞变形指数和刚性指数、红细胞压积、血浆黏度、纤维蛋白原及血沉。结果：与正常组比较，模型组全血高切、低切黏度和低切还原黏度明显升高（P＜0.01），高切还原黏度、红细胞刚性指数有所升高（P＜0.05）；与模型组比较，0.5 g/kg和1.0 g/kg 剂量的归附痛经颗粒能降低血瘀大鼠全血高切黏度、全血低切黏度和低切还原黏度（P＜0.01）。结论：归附痛经颗粒能改善寒凝血瘀证大鼠的血瘀状态。 |
| 关 键 词： | 药理学；归附痛经颗粒；寒凝血瘀证；血液流变性 |
| Title： | Effects of Guifutongjing granula on hemorheology of congealing cold and blood stasis rats |
| Author： | YU Ruihong, CAO Lei |
| Organization： | School of Medicine, Xi’an Jiaotong University |
| Abstract： | Objective: To observe the effects of Guifutongjing granula on hemorheology of congealing cold and blood stasis rats. Methods: We make the model of congealing cold and blood stasis in rats, and intragastric administration Guifutongjing granula for 1 week, then collect blood by abdominal aortic method and determine blood specific and reductive viscosity, erythrocyte deformation index and rigid index, hematocrit, plasma viscosity, fibrinogen and erythrocyte sedimentation rate. Results: Compared with normal group, high-shearrate blood viscosity, low-shearrate blood viscosity and low-shearrate reductive viscosity of model group increased greatly (P＜0.01), high-shearrate reductive viscosity and erythrocyte rigid index increased to some degree (P＜0.05). Compared with model group, 0.5 g/kg and 1.0 g/kg groups of Guifutongjing granula reduce high-shearrate blood viscosity, low-shearrate blood viscosity and low-shearrate reductive viscosity (P＜0.01). Conclusion: Guifutongjing granula can improve the blood stasis state of congealing cold and blood stasis rats. |
| Key words： | pharmacology; Guifutongjing granula; syndrome of congealing cold and blood stasis; hemorheology |
| 发表期数： | 2014年12月第23期 |
| 引用格式： | 于瑞红，曹蕾. 归附痛经颗粒对寒凝血瘀证模型大鼠血液流变性的影响[J]. 中国科技论文在线精品论文，2014，7（23）：2379-2382. |
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