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多孔HA/BaTiO3复合材料的制备及其生物活性研究
发表时间：2016-03-31 浏览量：2129 下载量：889
| 全部作者： | 张富强，邵春生，张斗，张妍，刘蓓蕾，陈良建，陈超，周科朝 |
| 作者单位： | 中南大学粉末冶金国家重点实验室； 湖南大学现代工程训练中心； 中南大学湘雅三医院 |
| 摘 要： | 研究羟基磷灰石/钛酸钡（HA/BaTiO3）复合生物压电陶瓷材料的结构和极化处理对MG63 细胞黏附、增殖和分化等功能的影响。采用冰模板法技术制备孔隙度为40%、50%、60%的多孔HA/BaTiO3 复合压电陶瓷材料，对其力学强度和压电效应进行表征。不同BaTiO3 含量的多孔HA/BaTiO3 与小鼠成纤维细胞L929 共同培养，用MTT 比色法进行细胞毒性实验，均未发现毒性反应；对50%孔隙率的HA/BaTiO3 复合材料，体外细胞实验发现单纯极化未施加载荷条件下多孔HA/BaTiO3 复合压电陶瓷材料对于促进MG63 黏附、增殖和分化作用不明显。用50%孔隙度的极化和未极化组HA/BaTiO3 进行动物实验，发现极化植入材料可能通过其压电效应影响骨生长，在骨生长早期就可以促进骨质的形成。 |
| 关 键 词： | 无机非金属材料；生物压电陶瓷；冷冻浇注；成骨细胞；增殖；分化 |
| Title： | Preparation of porous HA/BaTiO3 and its biological activity |
| Author： | ZHANG Fuqiang, SHAO Chunsheng, ZHANG Dou, ZHANG Yan, LIU Beilei, CHEN Liangjian, CHEN Chao, ZHOU Kechao |
| Organization： | State Key Laboratory of Powder Metallurgy, Central South University; Modern Engineering Training Center, Hunan University; The Third Xiangya Hospital, Central South University |
| Abstract： | The paper investigated the effects of different porosity and polarization treatments for porous HA/BaTiO3 biological piezoelectric ceramic on MG63 cell adhesion, proliferation and differentiation capabilities. In this study, porosity of 40%, 50%, 60% of HA/BaTiO3 were prepared in ice-templating method. The mechanical strength and piezoelectric effect had been used to characterize. With different contents of BaTiO3, porous HA/BaTiO3 cultivation together with the mouse fibroblast L929 line cytotoxicity experiment was determined by MTT method, which showed there was no toxic effect. For HA/BaTiO3 with porosity of 50%, through in vitro cell experiment, it was found that polarization was not obvious to promote MG63 effect on adhesion, proliferation and differentiation. Non-polarized and polarized HA/BaTiO3 with porosity of 50% were used for animals experiment. The results showed that polarization implant material may affect bone growth through its piezoelectric effect and promote bone formation of bone growth in the early years. |
| Key words： | inorganic nonmetallic materials; biological piezoelectric ceramic; freeze-casting; osteoblast; proliferation; polarization |
| 发表期数： | 2016年3月第6期 |
| 引用格式： | 张富强，邵春生，张斗，等. 多孔HA/BaTiO3复合材料的制备及其生物活性研究[J]. 中国科技论文在线精品论文，2016，9（6）：557-564. |
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