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n-HA/PA66对损伤胸腰椎骨生物力学属性的恢复效果研究
发表时间：2016-08-15 浏览量：1583 下载量：655
| 全部作者： | 沈 伟，林 峰，蒋雪梅 |
| 作者单位： | 重庆大学生物工程学院，生物流变科学与技术教育部重点实验室；北京大学工学院 |
| 摘 要： | 目的：研究经伤椎椎弓根植入纳米羟基磷石灰/聚酰胺（nanohydroxyapatite/polyamide-66，n-HA/PA66）复合人工骨粒对损伤胸腰椎体的生物力学属性的恢复效果，探究其临床应用价值。方法：选取10具人体T12-L2节段脊柱标本，将其随机平分为两组：自体松质骨组（cancellous bone，CB）与n-HA/PA66（NHP）组。椎体损伤后经椎弓根植入上述填充物，并自主设计夹具，利用万能试验机在轴向、前屈、后伸及侧弯四个方向测试椎体功能段T12-L2的刚度与椎体L1的应变。结果：与CB组相比，NHP组在轴向、前屈及侧弯方向上重建椎体刚度显著增加（P＜0.05），椎体L1应变显著降低（P＜0.05），表明NHP能较好地恢复损伤椎体的生物力学属性。结论：n-HA/PA66骨替代物比松质骨能更好地恢复损伤胸腰椎骨的生物力学性质，具有一定的临床应用价值。 |
| 关 键 词： | 生物力学；n-HA/PA66；自体骨移植；胸腰椎骨折 |
| Title： | Effects of n-HA/PA66 on the recovery of biomechanical properties for injured thoracolumbar vertebrae |
| Author： | SHEN Wei, LIN Feng, JIANG Xuemei |
| Organization： | Key Laboratory of Biorheological Science and Technology, Bioengineering College,Chongqing University; College of Engineering, Peking University |
| Abstract： | Objective: In this paper, the effects of nanohydroxyapatite/polyamide-66 (n-HA/PA66) as the transpedicular graft material in biomechanical properties in treating thoracolumbar fractures was addressed, and we investigated the value of clinic application. Methods: Ten T12-L2 vertebrae were harvested from human cadavers and randomly devided into two groups: cancellous bone (CB) and n-HA/PA66 (NHP). We implanted the graft material after vertebral injure, measured the stiffness of functional units (T12-L2) and strain of L1 by using of self-designed fixture and material testing machine. Results: Our results show that, compared to CB, the stiffness of T12-L2 was significantly increased in NHP (P＜0.05), and the strain of L1 was significantly decreased (P＜0.05), demonstrating that NHP can better recover the biomechanical properties of injured vertebra. Conlusion: n-HA/PA66 is better than cancellous bone in mechanics for reconstruction of thoracolumber fractures, which has certain clinical value. However, n-HA/PA66 grafts alone can not recover the biomechanical properties of injured vertebra to that of intact vertebrae, so further studies are needed. |
| Key words： | biomechanics; n-HA/PA66; autogenous bone graft; thoracolumbar fracture |
| 发表期数： | 2016年8月第15期 |
| 引用格式： | 沈 伟，林 峰，蒋雪梅. n-HA/PA66对损伤胸腰椎骨生物力学属性的恢复效果研究[J]. 中国科技论文在线精品论文，2016，9（15）：1587-1592. |
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