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抗癌天然产物土槿皮酸的全合成研究进展
发表时间：2017-07-13 浏览量：2172 下载量：983
| 全部作者： | 李云，郭瑞，翟宏斌 |
| 作者单位： | 兰州大学功能有机分子化学国家重点实验室 |
| 摘 要： | 土槿皮酸类化合物对于多种肿瘤细胞（肝癌、乳腺癌、宫颈癌、前列腺癌等）表现出良好的抗血管生成效果，从而抑制肿瘤细胞的增殖作用进而导致其凋亡。因此，针对该类化合物的全合成研究一直以来都是合成化学领域的热点。研究对重要抗癌天然产物土槿皮酸类似物的全合成展开综述，总结了近年来研究者对该类天然产物核心骨架的构建策略以及各种策略中合成挑战的巧妙解决方法，为该类分子的后续合成提供有益的启迪。 |
| 关 键 词： | 有机化学；天然产物全合成；综述；土槿皮酸；抗癌 |
| Title： | Advance research in the total synthesis of pseudolaric acids: an anticancer natural product |
| Author： | LI Yun, GUO Rui, ZHAI Hongbin |
| Organization： | State Key Laboratory of Applied Organic Chemistry, Lanzhou University |
| Abstract： | Pseudolaric acids display an anti-angiogenic role in a variety of cancer cell lines including hepatoma, breast, cervical and prostatic cancer, therefore they inhibit the proliferations of tumor cells. The total synthesis of this kind of compound has received considerable attentions from synthetic community. In this paper, recent advances in the total synthesis of pseudolaric acids analogs are reviewed. It shows the strategies in which the researchers have tried to construct their unique skeletons and the ways they have employed to solve the synthetic challenges. That information will benefit the synthetic strategies of pseudolaric acids in the future. |
| Key words： | organic chemistry; total synthesis of natural products; review; pseudolaric acids; anticancer |
| 发表期数： | 2017年7月第13期 |
| 引用格式： | 李云，郭瑞，翟宏斌. 抗癌天然产物土槿皮酸的全合成研究进展[J]. 中国科技论文在线精品论文，2017，10（13）：1425-1438. |
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