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静电纺三维大孔径微/纳米纤维复合支架的制备及力学性能
发表时间：2017-09-30 浏览量：1481 下载量：617
| 全部作者： | 张康兰，张静莹，董旭峰，张乃馨，齐民 |
| 作者单位： | 大连理工大学材料科学与工程学院；大连大学医学院 |
| 摘 要： | 制备具有大孔径三维结构的组织工程支架对人体组织修复具有重要意义。通过静电纺丝法，整合滚筒接收和水浴接收两种收集方式，制备聚乳酸/聚己内酯（PLA/PCL）质量比为1:1的微米级纤维束和纳米纤维复合三维组织工程支架。场发射扫描电子显微镜（field emission scanning electron microscope，FESEM）分析结果表明，电纺三维微/纳米纤维复合支架中微米级纤维束取向排列，直径为(40.83±15.40) μm，纳米级纤维无规排列，直径为(871±177) nm；复合支架的平均孔面积为(907.67±315.64) μm2，孔隙率为(91.89±3.48)%，均优于单一纳米纤维支架；复合支架与水的接触角为(109.74±3.02)°，其亲水性较传统电纺支架有所提高。拉伸试验结果表明，微/纳米纤维复合支架沿微米级纤维束排列方向的抗拉强度和断裂伸长率均大于垂直于纤维束方向的抗拉强度和断裂伸长率，表现出力学性能各向异性。 |
| 关 键 词： | 有机高分子材料；静电纺丝；组织工程；三维；大孔径 |
| Title： | Preparation and mechanical properties of electrospun three-dimensional large-pore size micro/nanofibrous composite scaffolds |
| Author： | ZHANG Kanglan, ZHANG Jingying, DONG Xufeng, ZHANG Naixin, QI Min |
| Organization： | School of Materials Science and Engineering, Dalian University of Technology; Medical College, Dalian University |
| Abstract： | Preparation of the tissue engineering scaffold with three-dimensional large-pore microstructure is significant to human tissue repair. In the present paper, the scaffold (PLA/PCL=1:1, mass ratio), composed of microfiber bundles and nanofibers, was prepared by electrospun with a modified receiving device based on roller receiving and bath receiving method. The field emission scanning electron microscope (FESEM) results showed that the microfiber bundles were directionally arranged with a diameter of (40.83±15.40) μm, and the nanofibers were randomly arranged with a diameter of (871±177) nm. The average pore area of composite scaffold was (907.67±315.64) μm2, and the porosity was (91.89±3.48)%, which were both superior to those ofthe single nanofibrous scaffold. Moreover, compared to traditional electrospun scaffold, the composite scaffold possessed an improved hydrophilicity with the smaller contact angle of water of (109.74±3.02)°. In addition, the mechanical test results presented that the tensile strength and elongation at break in the axial direction of microfiber bundles were both superior to those in the radial direction, which was indicative of the mechanical anisotropy of electrospun three-dimensional composite scaffold. |
| Key words： | organic macromolecule materials; electrospun; tissue engineering; three-dimension; large-pore size |
| 发表期数： | 2017年9月第18期 |
| 引用格式： | 张康兰，张静莹，董旭峰，等. 静电纺三维大孔径微/纳米纤维复合支架的制备及力学性能[J]. 中国科技论文在线精品论文，2017，10（18）：2079-2084. |
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