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Tim-3/Galectin-9途径在肝脏区域免疫调节中的作用
发表时间：2017-12-15 浏览量：2593 下载量：380
| 全部作者： | 叶于富，俞军，刘原兴，余松峰，彭一帆，郑树森 |
| 作者单位： | 浙江大学附属第一医院肝胆胰外科，卫生部多器官联合移植研究重点实验室；感染性疾病诊治协同创新中心 |
| 摘 要： | 肝脏是机体重要的免疫特惠器官。Tim-3/Galectin-9（Gal-9）信号通路在机体免疫调节、肿瘤免疫逃逸及免疫耐受中发挥重要作用。本文综述了Tim-3/Gal-9信号通路在肝移植免疫耐受、缺血再灌注损伤（ischemic reperfusion injury，IRI）、病毒性肝炎、自身免疫性肝炎（autoimmune hepatitis，AIH）、非酒精性脂肪性肝病（non-alcoholic fatty liver disease，NAFLD）、酒精性肝病（alcoholic liver disease，ALD）以及肝细胞肝癌（hepatocellular carcinoma，HCC）等疾病中的作用及相关机制，为将来应用研究奠定了理论基础。 |
| 关 键 词： | 外科学；肝脏区域免疫；综述；Tim-3；Galectin-9；免疫耐受 |
| Title： | Role of Tim-3/Galectin-9 in local control of the immune response in the liver |
| Author： | YE Yufu, YU Jun, LIU Yuanxing, YU Songfeng, PENG Yifan, ZHENG Shusen |
| Organization： | Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases |
| Abstract： | The liver is an immunologically privileged organ. The Tim-3/Galectin-9 (Gal-9) signaling pathway plays an important role in immune regulation, tumor immune escape and immune tolerance. This review summarizes the potential role and mechanisms of Tim-3/Gal-9 in various liver diseases, such as liver transplant tolerance, ischemia reperfusion injury (IRI), viral hepatitis, autoimmune hepatitis (AIH), non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD) and hepatocellular carcinoma (HCC), laying the theoretical foundations for future applied research. |
| Key words： | surgery; local hepatic immune; review; Tim-3; Galectin-9; immune tolerance |
| 发表期数： | 2017年12月第23期 |
| 引用格式： | 叶于富，俞军，刘原兴，等. Tim-3/Galectin-9途径在肝脏区域免疫调节中的作用[J]. 中国科技论文在线精品论文，2017，10（23）：2571-2576. |
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