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多巴胺及其受体在近视动物模型中作用的研究进展
发表时间：2018-09-14 浏览量：1838 下载量：387
| 全部作者： | 孙笑笑，郭芳，张琰，魏瑞华 |
| 作者单位： | 天津医科大学眼科医院，天津医科大学眼科研究所，天津医科大学眼视光学院 |
| 摘 要： | 近视已成为最常见的屈光不正，危害公众健康。在我国，青少年的近视患病率仍在逐年递增，形势严峻。然而，近视的发病机制尚不明确。神经递质多巴胺（dopamine，DA）及其受体在视网膜视觉传输通路中发挥着重要作用，调节眼球的生长发育。调控视网膜DA含量和DA受体的活性均能有效控制实验性近视的发生发展。本文对近年来DA和DA受体在近视动物模型中的干预作用研究进行总结，为进一步探索近视的发病机制、研发干预近视的药物提供新思路。 |
| 关 键 词： | 眼科学；近视；综述；多巴胺；多巴胺受体；发病机制 |
| Title： | Research advances on the role of dopamine and its receptors in myopic animal models |
| Author： | SUN Xiaoxiao, GUO Fang, ZHANG Yan, WEI Ruihua |
| Organization： | Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, School of Optometry and Ophthalmology, Tianjin Medical University |
| Abstract： | Myopia has become the most common refractive error, which can endanger the public health. In China, the prevalence of myopia among adolescents is still increasing year by year and the situation becomes severe. However, the pathogenesis of myopia remains unclear. The neurotransmitter dopamine (DA) and its receptors have emerged an important role in the retinal visual transmission pathway, regulating ocular growth and development. Changes of retinal DA content and DA receptor activity can effectively control the occurrence and development of experimental myopia. This paper will summarize the interventions of DA and DA receptors in myopia animal models, which may provide new ideas for exploring the pathogenesis of myopia and developing drugs to intervene myopia. |
| Key words： | ophthalmology; myopia; review; dopamine; dopamine receptors; pathogenesis |
| 发表期数： | 2018年9月第17期 |
| 引用格式： | 孙笑笑，郭芳，张琰，等. 多巴胺及其受体在近视动物模型中作用的研究进展[J]. 中国科技论文在线精品论文，2018，11（17）：1691-1698. |
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