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一种新型高灵敏氟-19磁共振成像分子的全合成

发表时间:2022-09-29  浏览量:573  下载量:64
全部作者: 韩明利,江中兴
作者单位: 武汉大学药学院
摘 要: 以儿茶酚为起始底物,通过七步反应高效简便地合成了含有72个氟原子的化合物9,化合物9以四苯并24-冠-8为母核,高度对称且具有单一的、强的氟信号,这为该分子在低浓度下的氟-19磁共振成像(fluorine-19 magnetic resonance imaging,19F MRI)提供了条件。该项工作提高了各步反应的产率,优化了反应步骤,大大缩短了反应时间,得到的终产物化合物9不仅具有结构上的新颖性,同时在氟-19磁共振成像方面具有非常好的应用前景。
关 键 词: 药物化学;氟-19磁共振成像(19F MRI);灵敏度高;无背景干扰
Title: Total synthesis of a novel highly sensitive fluorine-19 MRI molecule
Author: HAN Mingli, JIANG Zhongxing
Organization: School of Pharmaceutical Sciences, Wuhan University
Abstract: Using catechol as the initial substrate, compound 9 containing 72 fluorine atoms was efficiently and easily synthesized through a seven-step reaction. With tetrabenzo 24-crown-8 as the parent nucleus, compound 9 is highly symmetric and has single and intense fluorine signal, which provides the possibility for fluorine-19 magnetic resonance imaging (19F MRI) of this molecule at low concentrations. This work improves the yield of each step and optimizes the reaction steps, and the reaction time is greatly shortened. Besides, the final product compound 9 not only has structural novelty, but also has a good application prospect in 19F MRI.
Key words: pharmaceutical chemistry; fluorine-19 magnetic resonance imaging (19F MRI); high sensitivity; no background interference
发表期数: 2022年9月第3期
引用格式: 韩明利,江中兴. 一种新型高灵敏氟-19磁共振成像分子的全合成[J]. 中国科技论文在线精品论文,2022,15(3):328-331.
 
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