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近红外二区分子脂质体的制备与生物成像

发表时间:2022-12-29  浏览量:510  下载量:78
全部作者: 崔岩,徐福春
作者单位: 西藏大学医学院;西藏大学藏药现代化研发与藏药质量检测实验中心
摘 要: 本文探究了将近红外二区(second near-infrared region,NIR-II)小分子IR-FE制备为脂质体的方法,优化出最佳的脂质体配方。结果表明:物质量分数为95%的DPPC加5 %的DSPE-PEG2000是制备IR-FE脂质体的最佳配方,脂质体荧光强度随着投药浓度的改变没有变化,并且实现了对小鼠微血管的造影。这项工作为改善NIR-II小分子的水溶性提供了新的策略。
关 键 词: 制药工程;脂质体;近红外二区;荧光成像
Title: Preparation of liposomes loading NIR-II moleclues and their bioimaging
Author: CUI Yan, XU Fuchun
Organization: School of Medicine, Tibet University; Innovation Center for Traditional Tibetan Medicine Modernization and Quality Control, Tibet University
Abstract: The preparation method of liposomes loading second near-infrared region (NIR-II) molecule IR-FE was explored. The optimal liposome formulation was obtained. The investigations indicate that 95% (mole fraction) DPPC and 5% (mole fraction) DSPE-PEG2000 is the best formulation for preparing IR-FE liposomes. The fluorescence intensity of liposomes does not change with the change of administered dose. And the microangiography of mouse vessels is achieved. This work provides a new strategy to improve the water solubility of NIR-II molecule.
Key words: pharmaceutical engineering; liposome; second near-infrared region (NIR-II); fluorescence imaging
发表期数: 2022年12月第4期
引用格式: 崔岩,徐福春. 近红外二区分子脂质体的制备与生物成像[J]. 中国科技论文在线精品论文,2022,15(4):551-557.
 
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