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失重所致股骨松质骨丢失的有限元仿真

发表时间:2008-08-15  浏览量:1456  下载量:649
全部作者: 彭亮,尚禹,白净
作者单位: 清华大学生物医学工程系
摘 要: 航天飞行中失重所引起的力学环境改变会显著影响骨重建过程,基于CT数据重建了人的右端股骨模型,提出了一种带有“饱和区”的骨再造算法,并用该算法仿真了失重情况下股骨松质骨骨量丢失情况,仿真由有限元方法结合迭代过程来实现。结果与实际观察的航天骨丢失结果一致:失重时间越长,则骨丢失越严重;同时,股骨不同部位的骨丢失情况不一样,近端骨丢失较中端和末端要严重得多,其中股骨颈的骨量下降最多。这一结论可为今后研究失重情况下骨量丢失规律及研制有效对抗失重的措施提供一定的依据。
关 键 词: 生物医学工程;失重;骨再造;骨丢失;股骨;有限元
Title: The simulation of trabecular bone loss of femur due to weightlessness using finite element method
Author: PENG Liang, SHANG Yu, BAI Jing
Organization: Department of Biomedical Engineering, Tsinghua University
Abstract: The change of mechanical environment will significantly affect the bone remodeling during space aviation. In this study, the right femoral model was reconstructed based on the CT data. A new bone adaptation algorithm with “saturation area” was brought forward and used to simulate bone loss under weightlessness. The simulation was implemented by combining the finite element method and iteration process. The simulation results are consistent with the actual observation of bone loss caused by weightlessness. The longer duration of weightlessness will lead to the more bone loss. Besides that, different ratio of bone loss was found in different location. The bone loss is higher in proximal femur than that in middle and distal femur. Among this, the bone quality declines most in femoral neck. These findings are useful for further investigation of bone loss due to weightlessness and developing efficient countermeasure to retain bone mass.
Key words: biomedical engineering; weightlessness; bone remodeling; bone loss; femur; finite element
发表期数: 2008年12月第15期
引用格式: 彭亮,尚禹,白净. 失重所致股骨松质骨丢失的有限元仿真[J]. 中国科技论文在线精品论文,2008,1(15):1678-1683.
 
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