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散发性乳腺癌组织中乳腺癌易感基因表达相关因素分析

发表时间:2009-06-15  浏览量:1461  下载量:546
全部作者: 任婕,魏敏杰,马文峰,王麟,金锋,米小轶,金万宝
作者单位: 中国医科大学药学院;中国医科大学第一附属医院外科;中国医科大学基础医学院
摘 要: 检测121例散发性乳腺癌和20例乳腺良性病变组织石蜡标本的BRCA1,ER和HER-2蛋白表达,结合患者的年龄、原发肿瘤的病理类型和腋淋巴结转移状况等病理学指标,分析影响BRCA1蛋白表达的因素及与临床病理特征之间的相关性。研究表明:乳腺良性病变组织中BRCA1,ER蛋白均在细胞核阳性表达;散发性乳腺癌组织中,BRCA1,ER蛋白表达明显降低,BRCA1,ER蛋白表达在良、恶性乳腺病变组织之间均有显著性差异(P<0.05)。HER-2阳性表达的乳腺癌组织中,BRCA1阳性表达率降低,BRCA1蛋白表达与HER-2过表达呈负相关。BRCA1蛋白表达与年龄呈负相关,低年龄组BRCA1蛋白表达阳性率高于高年龄组(P<0.05);BRCA1蛋白表达与腋淋巴结转移呈负相关,有腋淋巴结转移的BRCA1表达降低得更显著(P<0.05);BRCA1蛋白表达与乳腺癌的病理类型未见明显相关性。研究结果提示:检测BRCA1蛋白水平结合ER,HER-2的表达和临床资料,对乳腺癌的诊断和判断预后有指导意义。
关 键 词: 分子肿瘤学;散发性乳腺癌;BRCA1;ER;HER-2
Title: Correlation analysis of expression of BRCA1 protein and related factors in sporadic breast cancer
Author: REN Jie, WEI Minjie, MA Wenfeng, WANG Lin, JIN Feng, MI Xiaoyi, JIN Wanbao
Organization: College of Pharmacy, China Medical University;Surgical Department, the First Hospital of China Medical University;Basic College of China Medical University
Abstract: This paper selected 121 sporadic breast cancer and 20 benign breast diseases, the expression level of BRCA1, ER and HER-2 protein was detected by immunohistochemistry (IHC). The factors affect the expression of BRCA1, and the correlation between expression of BRCA1 and the clinical parameters were analyzed. In the benign breast tissues, the positive expression of BRCA1 and ER protein are found in the nuclei. While in the breast cancer tissues, there are low or loss expression of BRCA1 and ER protein, the differences are significant (P<0.05). There is negative correlation between the expression of BRCA1 and over expression of HER-2. The expression of BRCA1 in breast cancer is negatively correlated with the age of patient. The expression of BRCA1 protein is negatively correlated with the metastasis of axillary lymph nodes. The expression of BRCA1 with axillary lymph hode metastasis decreases more significantly. There is no significant correlation between the BRCA1 protein expression and the pathology types of the breast cancer. The detection of BRCA1 expression combining with the expression of ER and HER-2, together with the clinical parameters, is beneficial to the diagnosis and prognosis of sporadic breast carcinoma.
Key words: molecular oncology; sporadic breast cancer; BRCA1; ER; HER-2
发表期数: 2009年6月第11期
引用格式: 任婕,魏敏杰,马文峰,等. 散发性乳腺癌组织中乳腺癌易感基因表达相关因素分析[J]. 中国科技论文在线精品论文,2009,2(11):1137-1141.
 
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