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代谢综合征患者动脉脉搏波速与C5a,CRP的关系研究

发表时间:2009-06-15  浏览量:1431  下载量:676
全部作者: 方砚,刘永铭,王小玉
作者单位: 甘肃省人民医院干部病房
摘 要: 目的:探讨炎症标志物C5a,C反应蛋白(C reactive protein, CRP)与动脉脉搏波速(pulse wave velocity,PWV)的关系。方法:代谢综合征(metabolic syndrome,MS)患者26例,非代谢综合征患者34例作为对照,测定血清C5a,CRP,尿C5a及PWV,分析其关系。结果:与对照组比较,代谢综合征组尿C5a及颈动脉-股动脉脉搏波速度(cf-PWV)明显高于非代谢综合征组,两组比较,血清C5a,CRP,颈-挠动脉脉搏波速度(cr-PWV),颈-足背动脉脉搏波速度(cd-PWV)无统计学差异;cf-PWV与年龄、收缩压、尿C5a呈正相关,与血清CRP,C5a不相关;cd-PWV与尿C5a,年龄相关。结论:代谢综合征患者PWV增快,尿C5a浓度增高,PWV与尿C5a相关。
关 键 词: 内科学;代谢综合征;动脉粥样硬化;补体;动脉脉搏波速度
Title: A study of the relationship between complements (C5a and CRP) and pulse wave velocity in patients with metabolic syndrome
Author: FANG Yan, LIU Yongming, WANG Xiaoyu
Organization: Cadre Ward, People’s Hospital of Gansu Province
Abstract: Objective: To investigate the relationship between complements (C5a and CRP) and pulse wave velocity (PWV) in patients with metabolic syndrome (MS). Methods: Twenty-six patients with MS were recruited in this study and thirty-four persons without MS served as a contrast group. Serum C5a, serum CRP, urine C5a, and PWV were examined, and the relationships among them were analyzed. Results: Compared with those of the contrast group, the urine C5a and cf-PWV of the MS patient group were significantly higher, but the two groups had no statistical difference in the serum C5a, serum CRP, cr-PWV and cd-PWV; the cf-PWV was positively correlated with age, systolic pressure and the urine C5a, but was not correlated with the serum CRP and C5a; and the cd-PWV was positively correlated with the urine C5a and age. Conclusion: The MS patient group has increased PWV and urine C5a concentration, and the PWV is correlated with the urine C5a.
Key words: internal medicine; metabolic syndrome; atherosclerosis; complement; pulse wave velocity
发表期数: 2009年6月第11期
引用格式: 方砚,刘永铭,王小玉. 代谢综合征患者动脉脉搏波速与C5a,CRP的关系研究[J]. 中国科技论文在线精品论文,2009,2(11):1153-1156.
 
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