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应用三态跃迁模型研究NaK通道的通透机制
发表时间：2009-08-15 浏览量：1691 下载量：713
| 全部作者： | 李颖，于慧，安海龙，张振东，李军委，展永 |
| 作者单位： | 河北工业大学生物物理研究所 |
| 摘 要： | 从NaK通道的三维精细结构出发，构造了反映通道与离子相互作用的位能曲线，在此基础上建立了描述离子通透过程的三态跳跃模型，并运用主方程求解得到了NaK通道稳态下的电流-电压、电流-浓度关系等重要生理学特征，比较了K+和Na+在NaK通道中通透过程的动力学特征。此外，还讨论了NaK通道三态跃迁模型的暂态特征以及特征时间随电压、离子浓度的变化关系。所得结果与实验数据可以较好地吻合。 |
| 关 键 词： | 生物物理学；NaK通道；选择性；三态跃迁模型；主方程 |
| Title： | Research on the permeation mechanism of NaK channel based on a tri�state hopping model |
| Author： | LI Ying, YU Hui, AN Hailong, ZHANG Zhendong, LI Junwei, ZHAN Yong |
| Organization： | Institute of Biophysics, Hebei University of Technology |
| Abstract： | The three�dimensional fine structure of NaK channel was used for building the potential curve of ions combined with channel and the tri�state hopping model which demonstrates the permeation process of ions, and current�voltage and current�concentration relationships in steady�state were derived from the master equation. The kinetic characteristics of K+ and Na+ permeation processes in NaK channel were compared. In addition, the transient characteristics of NaK channel were discussed, as well as the characteristic time in relation to the voltage and ion concentration. The results are in good agreement with experiment. |
| Key words： | biophysics; NaK channel; selectivity; tri�state hopping model; master equation |
| 发表期数： | 2009年8月第15期 |
| 引用格式： | 李颖，于慧，安海龙，等. 应用三态跃迁模型研究NaK通道的通透机制[J]. 中国科技论文在线精品论文，2009，2（15）：1596-1603. |
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