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利用反向疫苗学筛选保护性抗原的研究

发表时间:2009-10-15  浏览量:1583  下载量:569
全部作者: 宋振威,周学章,王玉炯
作者单位: 宁夏大学西部特色生物资源保护与利用教育部重点实验室
摘 要: 近年发展起来的反向疫苗学(reverse vaccinology),是现代疫苗学研究的一种新的策略,使疫苗学的研究进入了一个新的时期。这种以“序列-结构-功能”思想为依据,以免疫学、计算机信息学以及高通量的组学(包括基因组学、转录组学、蛋白质组学等)综合集成技术为核心的策略,为多种病原微生物保护性抗原的筛选提供新策略,可以大大提高筛选疫苗的效率。
关 键 词: 基因工程;反向疫苗学;综述;筛选保护性抗原
Title: Research on application of reverse vaccinology in protective antigen screening
Author: SONG Zhenwei, ZHOU Xuezhang, WANG Yujiong
Organization: Key Laboratory of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China, Ningxia University
Abstract: The rapidly-developed reverse vaccinology was a new strategy on the modern study of vaccinology, which marked a turning point. Based on the principle of “sequence-structure-function”, the strategy taked immunization information science、computer prediction design and high-throughput of the various groups (including genomics, transcription of this group, proteomics and so on) as its core. It was hoped that the strategy can give new lights to find more protective antigen of pathogen as the candidates to produce vaccine, and improve our efficiency to vaccine screening.
Key words: genetic engineering; reverse vaccinology; review; screening protective antigen
发表期数: 2009年10月第19期
引用格式: 宋振威,周学章,王玉炯. 利用反向疫苗学筛选保护性抗原的研究[J]. 中国科技论文在线精品论文,2009,2(19):1987-1993.
 
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