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补肾抗衰片对实验性动脉粥样硬化的NF-κB及炎症因子的影响
发表时间：2009-12-15 浏览量：2076 下载量：835
| 全部作者： | 张军平，许颖智，李明，李良军，彭立，张光银，杨萃，周亚男 |
| 作者单位： | 天津中医药大学第一附属医院；天津中医药大学研究生院 |
| 摘 要： | 目的：探讨补肾抗衰片对家兔动脉粥样硬化（atherosclerosis，AS）的干预及作用机制。方法：将36只雄性日本大耳白兔随机分为4组：正常对照组、模型组、辛伐他汀组、补肾抗衰组。正常对照组饲喂普通饲料；模型组和给药组建立动脉粥样硬化家兔模型，辛伐他汀组及补肾抗衰组从第1周开始分别加喂辛伐他汀片和补肾抗衰片，直至第10周取材。测定各组血脂、自介素-1（interleukin-1,IL-1）、单核细胞趋化因子（monocyte chemoattractant protein-1, MCP-1)、肿瘤坏死因子-α（tumor necrosis factor-α, TNF-α)及第10周时主动脉壁核因子-κB（nuclear factor-kappa B, NF-κB)的表达，病理检测主动脉斑块与内膜面积比（plaque area/intimal area,PA/IA)、内膜中膜厚度比（intimal tlvickness/media thickness, IT/MT）、IT、内膜增生指数（intinal hyperplasia index, IHI)。 结果：与正常对照组比较，各时间点模型组血脂水平及炎症因子水平显著增高（P＜0.01)，主动脉PA/IA，IT，IHI均有不同程度升高（P＜0.01）。两给药组各时间点的血清IL-1，MCP-1，TNF-α及动脉壁NF-κB表达，以及PA/IA，IT，IHI均有不同程度的降低（P＜0.05，P＜0.01）。结论：补肾抗衰片可抑制动脉粥样硬化家兔模型的炎症反应，抗动脉粥样硬化形成，且作用和血脂水平无直接的相关性。 |
| 关 键 词： | 中医内科学；补肾抗衰片；动脉粥样硬化斑块；核因子-κB；炎症细胞因子 |
| Title： | Effect of Bushen Kangshuai tablet on NF-κB and inflammation factors in rabbit with experimental atherosclerosis |
| Author： | ZHANG Junping, XU Yingzhi, LI Ming, LI Liangjun, PENG Li, ZHANG Guangyin, YANG Cui, ZHOU Yanan |
| Organization： | The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine；Graduate School, Tianjin University of Traditional Chinese Medicine |
| Abstract： | Objective: To observe the intervening effect and acting mechanism of Bushen Kangshuai tablet (BKT) on rabbit\'s atherosclerosis (AS). Methods: Thirty-six male Japanese white rabbits were randomly assigned into four groups: control group, model group, and the simvastatin group the BKT group. The AS model was established. The medication of simvastatin and BKT was given in the whole 10-week course. Levels of blood lipid, interleukin-1(IL-1), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-α (TNF-α) were measured. The nuclear factor-kappa B (NF-κB) expression in aortic wall, ratio of plaque area to intimal area (PA/IA), intimal thickness (IT), and intimal hyperplasia index (IHI) were measured at the terminal of experiment. Results: Compared with the normal control group, all indexes of the blood lipids and inflammation factors measured at various time points, and the PA/IA, as well as IHI in the model group were higher (P＜0.01). Compared with the model group, the levels of IL-1, MCP-1, TNF-α, NF-κB as well as the ratios of PA/IA and IHI were lower in the two treated groups at all time points after treatment (P＜0.01 or P＜0.05). Conclusion: BKT can suppress the inflammation reaction in rabbits to prevent AS formation, and the action is not directly correlated with the blood lipids level. |
| Key words： | internal Chinese medicine science; Bushen Kangshuai tablet; plaque of atherosclerosis; nuclear factor-κB; inflammation factor |
| 发表期数： | 2009年12月第23期 |
| 引用格式： | 张军平，许颖智，李明，等. 补肾抗衰片对实验性动脉粥样硬化的NF-κB及炎症因子的影响[J]. 中国科技论文在线精品论文，2009，2（23）：2489-2495. |
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