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类风湿性关节炎伴发抑郁大鼠的行为学测定

发表时间:2009-12-15  浏览量:1493  下载量:529
全部作者: 郑琴,朱跃兰,侯秀娟
作者单位: 北京中医药大学东方医院风湿科
摘 要: 目的:通过对大鼠行为学指标的观察,评价类风湿性关节炎伴发抑郁大鼠模型。方法:胶原诱导复制大鼠类风湿性关节炎模型,结合孤养法和慢性不可预知的温和应激方法,造成类风湿性关节炎伴发抑郁大鼠模型,造模后给予行为学测定。结果:模型组大鼠关节肿大畸形,关节炎指数增高,蔗糖水饮用量、旷野实验中水平及垂直得分都明显小于正常组,有非常显著性差异(P<0.01)。结论:类风湿性关节炎伴发抑郁症大鼠关节肿大畸形、关节炎指数增高、抑郁状态、兴趣丧失、运动迟滞等,能充分模拟类风湿性关节炎伴发抑郁患者的核心症状,实验重复性较好,是研究类风湿性关节炎伴发抑郁的理想模型。
关 键 词: 中医内科学;类风湿性关节炎伴发抑郁;大鼠;行为学测定
Title: Behavioral test of rats with post-rheumatoid arthritis depression
Author: ZHENG Qin, ZHU Yuelan, HOU Xiujuan
Organization: Department of Rheumatology, Dongfang Hospital of Beijing University of Chinese Medicine
Abstract: Objective: To evaluate the rat model of post-rheumatoid arthritis depression by behavioral indicators observed in rats. Methods: The rats were induced arthritis with type Ⅱ collagen first, and then the rats were separately raised and put into chronic unpredictable mild stress in order to induce the model of post-rheumatoid arthritis depression. After undergoing the model-inducing procedures, the rats were examined by behavioral test. Results: It was found that ankle joints were swollen and malformed, the index of arthritis was increasing, the amount of sugar-water consumption by the rats in the model group, both the crossing time and rearing time in the open-field test were much less than those by the rats in the normal group (P<0.01). Conclusion: With swollen and malformed ankle joints,increasing of the index of arthritis, depression, loss of interest, anhedonia and underactivity found in the rats with post-rheumatoid arthritis depression may represent the core symptoms in the patients of post-rheumatoid arthritis depression. The model is repeatable and is an ideal model for post-rheumatoid arthritis depression research.
Key words: internal Chinese medicine science; post-rheumatoid arthritis depression; rats; behavioral test
发表期数: 2009年12月第23期
引用格式: 郑琴,朱跃兰,侯秀娟. 类风湿性关节炎伴发抑郁大鼠的行为学测定[J]. 中国科技论文在线精品论文,2009,2(23):2501-2503.
 
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