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养肺活血方对博莱霉素诱发大鼠肺间质纤维化的干预作用

发表时间:2009-12-15  浏览量:1867  下载量:626
全部作者: 郭海,龚婕宁,魏凯峰,张庆宏,董丽霞
作者单位: 南京中医药大学基础医学院;江苏省高邮市中医医院内科
摘 要: 目的:探讨养肺活血方对博莱霉素诱发大鼠肺间质纤维化的干预作用。方法:采用气管内注入博莱霉素A5建立肺间质纤维化的大鼠模型,将98只大鼠随机分为7组,分别给予养肺活血方等相应的药物,肺组织常规行苏木素伊红(hematoxylin eosin, HE)染色和Masson三色染色,观察肺泡炎和肺纤维化程度。结果:养肺活血方能够明显减轻大鼠的肺泡炎和纤维化程度(P<0.01)。结论:中药养肺活血方对博莱霉素复制的肺纤维化大鼠模型有良好的防治作用。
关 键 词: 中医临床基础;肺纤维化;养肺活血方;实验研究
Title: Intervention of Yangfei Huoxue prescription on bleomycin-induced pulmonary fibrosis in rats
Author: GUO Hai, GONG Jiening, WEI Kaifeng, ZHANG Qinghong, DONG Lixia
Organization: The Pre-clinical Medicine College, Nanjing University of Chinese Medicine;The Pre-clinical Medicine College, Nanjing University of Chinese Medicine;Internal Medicine, Gaoyou Hospital of Chinese Medicine
Abstract: Objective: To determine whether Yangfei Huoxue prescription can prevent bleomycin-induced pulmonary fibrosis in rats. Methods: Ninety-eight rats were randomly divided into seven groups and were intratracheally infused with bleomycin to build the model. Then every group received corresponding medicine. Finally, the lungs of rats were dyed by HE and Masson. Results: Yangfei Huoxue prescription could obviously decrease degree of bleomycin-induced pulmonary fibrosis in rats (P<0.01). Conclusion: Yangfei Huoxue prescription has an obvious intervention in the treatment of bleomycin-induced pulmonary fibrosis.
Key words: clinical foundation of Chinese medicine; pulmonary fibrosis; Yangfei Huoxue prescription; experimental study
发表期数: 2009年12月第23期
引用格式: 郭海,龚婕宁,魏凯峰,等. 养肺活血方对博莱霉素诱发大鼠肺间质纤维化的干预作用[J]. 中国科技论文在线精品论文,2009,2(23):2504-2510.
 
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