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腺嘌呤肾阳虚多尿模型的研制
发表时间：2009-12-15 浏览量：1860 下载量：790
| 全部作者： | 吴清和，黄萍，操红缨 |
| 作者单位： | 广州中医药大学中药学院 |
| 摘 要： | 目的：制作腺嘌呤致肾阳虚多尿大鼠模型。方法：SD(Sparague-Dawley)大鼠分别用腺嘌呤350，300，250，150 mg/kg灌胃，1次/d，连续4周。观察大鼠一般状态的改变，检测体重及尿量的变化。结果：用腺嘌呤250 mg/kg灌胃的动物模型出现肾阳虚的症状，没有出现死亡并且出现明显的多尿症状。结论：腺嘌呤可以制作较理想的肾阳虚多尿大鼠模型。 |
| 关 键 词： | 中药药理学；腺嘌呤；肾阳虚多尿；模型 |
| Title： | Model establishment method of rat polyuria due to kidney Yang-deficiency |
| Author： | WU Qinghe, HUANG Ping, CAO Hongying |
| Organization： | School of Chinese Materia Medica, Guangzhou University of Chinese Medicine |
| Abstract： | Objective: To establishment a model of rat polyuria due to Kidney Yang-deficiency. Methods: Sparague-Dawley (SD) rats were induced independently by adenine (350, 300, 250, 150 mg/kg) for 4 weeks. The general state, weight and urine of the rats were observed. Results: Rats induced by adenine of 250 mg/kg were not dead, and they all appeared the syndrome of kidney Yang-deficiency and polyuria. Conclusion: Adenine can be used to establish the model of the rat polyuria due to kidney Yang-deficiency. |
| Key words： | pharmacology of Chinese medicine; adenine; polyuria due to kidney Yang-deficiency; model |
| 发表期数： | 2009年12月第23期 |
| 引用格式： | 吴清和，黄萍，操红缨. 腺嘌呤肾阳虚多尿模型的研制[J]. 中国科技论文在线精品论文，2009，2（23）：2528-2531. |
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