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植物内源非编码小RNA研究进展:生物信息学分析与相关数据库

发表时间:2010-04-15  浏览量:2319  下载量:1065
全部作者: 王煜,樊龙江
作者单位: 浙江大学农学系
摘 要: 内源性非蛋白质编码小RNA (small non-protein-coding RNA, 12~24 nt)广泛存在于高等和低等生物体内,通过对靶标mRNA直接切除或抑制其翻译在转录后水平对基因表达起调节作用。已知的小RNA主要分为两大类:一类是微小RNA (microRNA, miRNA),另一类是小干扰RNA (small interfering RNA, siRNA).生物信息学方法是小RNA研究的一个重要组成部分。大量的计算方法、相关软件和小RNA数据不断产生,主要介绍内源性非编码小RNA的计算识别与靶基因预测,以模式作物水稻为例介绍了小RNA进化与选择方面的研究进展,并介绍了相关小RNA数据库的基本信息。
关 键 词: 生物信息学;内源非编码小RNA;综述;微小RNA;小干扰RNA;miRBase
Title: Research progress of small non-protein-coding RNAs: introduction of bioinformatic analysis and related databases
Author: WANG Yu, FAN Longjiang
Organization: Department of Agronomy, Zhejiang University
Abstract: Small non-protein-coding RNAs (12~24 nt) broadly exist in both eucaryotes and prokaryotes, and regulate gene expression through direct cleavage of the target mRNAs or suppression the translation in post-transcriptional level. Known small RNAs can mainly be classified into two groups: microRNA (miRNA) and small interfering RNA (siRNA). Bioinformatics methods can help the analysis of small RNAs effectively. As the appearance and increasing of the related computational methods, softwares and small RNA databases, it’s necessary to introduce the research progress about the computational identification of small RNAs and prediction of target genes, and the information of related small RNA databases.
Key words: bioinformatics; small non-protein-coding RNAs; review; microRNA; small interfering RNA; miRBase
发表期数: 2010年4月第7期
引用格式: 王煜,樊龙江. 植物内源非编码小RNA研究进展:生物信息学分析与相关数据库[J]. 中国科技论文在线精品论文,2010,3(7):639-649.
 
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