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头孢唑啉钠溶解度的测定与关联

发表时间:2010-09-15  浏览量:1478  下载量:486
全部作者: 金海红,李玉,任保增
作者单位: 郑州大学化工与能源学院
摘 要: 使用激光监视技术,在常压条件下,测量293.15~317.15 K下头孢唑啉钠在乙醇和二甲亚砜混合物(溶剂组成:乙醇物质的量分数为0~0.9)中的溶解度。在乙醇和二甲亚砜二相混合溶剂中头孢唑啉钠的溶解度随温度的升高而增加,随溶剂组成中乙醇含量的增加而下降。实验数据分别使用Apelbat方程和CNIBS/Redlich-Kister(CNIBS/R-K)方程进行关联。对10组溶解度数据进行研究发现:CNIBS/Redlich-Kister方程对实验数据能够提供更准确的数学表征。所测定的溶解度数据和关联模型可以作为基础热力学数据和模型在头孢唑啉钠结晶过程中应用。
关 键 词: 化学热力学;头孢唑啉钠;激光监视技术;溶解度
Title: Determination and correlation of cefazolin sodium solubility
Author: JIN Haihong, LI Yu, REN Baozeng
Organization: School of Chemical Engineering and Energy, Zhengzhou University
Abstract: Using a laser monitoring observation technique, the solubility values of cefazolin sodium in dimethyl sulfoxide and ethanol mixtures were measured at temperatures from 293.15 to 317.15 K at atmospheric pressure with the solvent mole fraction composition ranged from 0 to 0.9. The solubility of cefazolin sodium is increases with an increase of temperature in dimethyl sulfoxide and ethanol binary solvent mixture. Simultaneously, the solubility decreases with an increase of concentration of ethanol in the solvent mixture. The experimental data were correlated with the modified Apelbat equation and CNIBS/Redlich-Kister equation, respectively. For the ten group solubility data studied, the CNIBS/Redlich-Kister equation was found to provide a more accurate mathematical representation of the experimental data. The experimental solutility data and the correlation equation can be used as the basis of thermodynamic data and the model applied in the crystallization process of cefazolin sodium.
Key words: chemical thermodynamics; cefazolin sodium; laser monitoring observation technique; solubility
发表期数: 2010年9月第17期
引用格式: 金海红,李玉,任保增. 头孢唑啉钠溶解度的测定与关联[J]. 中国科技论文在线精品论文,2010,3(17):1813-1819.
 
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