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同卵与异卵双生子糖尿病-肾虚证病证结合比较分析

发表时间:2010-12-15  浏览量:1366  下载量:471
全部作者: 谭从娥,倪青,张天娥,冯文哲,陈康,王米渠
作者单位: 陕西中医学院中医诊断学教研室;中国中医科学院广安门医院内分泌科;成都中医药大学基础医学院;陕西中医学院附属医院
摘 要: 目的:比较不同卵型[同卵(monozygotic, MZ)或异卵(dizygotic, DZ)]双生子之间病和证的异同,探讨糖尿病、肾虚证的遗传特性。方法:从2型糖尿病(type 2 diabetes mellitus,T2DM)家系中筛选到3对双生子,通过临床调查及实验室检查(空腹血糖、糖耐量实验及糖化血红蛋白等)确诊是否患T2DM;然后根据双生子相似诊断法判断其卵型,并采用专家诊断与量表计分相结合的方式判别3对双生子肾虚证的有无;最后通过肾虚主证和四诊症状总计分的比较,分析同卵和异卵双生子之间病和证的异同。结果:3对双生子中,2对为同卵双生子,1对为异卵双生子。2对同卵双生子皆为T2DM肾虚证,但病史和病情程度不同;1对异卵双生子一个为T2DM患者,另一个为糖耐量损伤(impaired glucose tolerance,IGT),其中,T2DM患者主证为肾虚证,但IGT者无肾虚证。结论:T2DM和肾虚证有伴发倾向;双生子患病和证具有一致性,同卵双生子比异卵双生子病证一致性的特点更为突出。
关 键 词: 中西医结合医学;糖尿病;肾虚证;同卵双生;异卵双生
Title: Comparison of integrated diabetes mellitus and kidney deficiency syndrome between monozygotic and dizygotic twins
Author: TAN Conge, NI Qing, ZHANG Tiane, FENG Wenzhe, CHEN Kang, WANG Miqu
Organization: Department of Traditional Chinese Medicine Diagnostics, Shaanxi University of Traditional Chinese Medicine; Department of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences; Institute of Basic Medicine, Chengdu University of Traditional Chinese Medicine; Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine
Abstract: Objective: To compare the similarities and differences of both disease and TCM syndrome between monozygotic (MZ) and dizygotic (DZ) twins, and further explore the genetic characteristics of type 2 diabetes mellitus (T2DM) with kidney deficiency syndrome. Methods: Firstly, three pairs of twins were screened from T2DM pedigrees through clinical investigation and laboratory tests (fasting blood glucose, glucose tolerance tests and glycosylated hemoglobin). Secondly, the zygosity of each pair of twins was determined through the method of twin’s phenotype similarity comparison. Finally, the kidney deficiency syndrome of 3 pairs of twins was decided by traditional Chinese medicine (TCM) experts and questionnaire scores. Results: Among three pairs of twins, two pairs were MZ and one pair was DZ. Two pairs of MZ twins suffered with both T2DM and kidney deficiency syndrome. One of DZ twins was diagnosed with T2DM and kidney deficiency syndrome and the other was diagnosed with no kidney deficiency syndrome but impaired glucose tolerance (IGT). Conclusion: The differentiated results of 3 pairs of twins suggest that kidney deficiency syndrome is liable to be accompanied with T2DM. There is consistency of suffering T2DM and kidney deficiency comsyndrome between MZ twins although the differences in severity of illness are obvious.
Key words: medicine combined with Chinese traditional medicine and western medicine; diabetes mellitus; kidney deficiency syndrome; monozygotic twin; dizygotic twin
发表期数: 2010年12月第23期
引用格式: 谭从娥,倪青,张天娥,等. 同卵与异卵双生子糖尿病-肾虚证病证结合比较分析[J]. 中国科技论文在线精品论文,2010,3(23):2449-2454.
 
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