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基于葡萄糖和苯硼酸基元间可逆共价键构筑多重响应性高分子复合物胶束

发表时间:2011-04-15  浏览量:1634  下载量:502
全部作者: 王頔,刘世勇
作者单位: 中国科学技术大学化学与材料科学学院
摘 要: 通过可逆加成-断裂链转移(reversible addition-fragmentation chain transfer, RAFT)的聚合方法,合成了分别含有苯硼酸基元和葡萄糖基元的聚(N-异丙基丙烯酰胺)-b-聚(丙烯酰胺基苯硼酸)(PNIPAM-b-PAPBA)和聚(N-异丙基丙烯酰胺)-b-聚(丙烯酰葡萄糖胺)(PNIPAM-b-PAGA)二嵌段聚合物。由于苯硼酸和葡萄糖基元之间在弱碱性条件下(pH=9.3)形成硼酸酯共价键,2种二嵌段聚合物的水溶液混合后能自发形成以PAPBA/PAGA络合物为核、PNIPAM为壳层的高分子复合物胶束。由于硼酸酯共价键在pH值和葡萄糖浓度改变时能可逆形成和断裂,以及胶束PNIPAM壳层的温敏性,所制备的基于苯硼酸/葡萄糖可逆共价键的高分子复合物胶束对pH值、葡萄糖和温度具有多重响应性。
关 键 词: 高分子化学;复合物胶束;科学实验法;可逆共价键;多重响应性
Title: Fabrication of multi-responsive interpolymer complex micelles based on reversible covalent bond formation among phenylboronic acid and glucose moieties
Author: WANG Di, LIU Shiyong
Organization: School of Chemistry and Materials Science, University of Science and Technology of China
Abstract: Two types of diblock copolymers containing phenylboronic acid and glucose moieties, respectively, poly(N-isopropylacrylamide)-b-poly(N-acryloyl-3-aminophenylboronic acid) (PNIPAM-b-PAPBA) and poly(N-isopropylacrylamide)-b-poly(acryloyl glucosamine) (PNIPAM-b-PAGA) were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Due to the formation of borate ester functionalities between phenylboronic acid and glucose moieties under slightly alkaline conditions (pH=9.3), mixed solution of PNIPAM-b-PAPBA and PNIPAM-b-PAGA diblock copolymers can spontaneously form interpolymer complex micelles consisting of PAPBA/PAGA complex cores and PNIPAM coronas. Since the formation/cleavage of borate ester linkages is highly reversible upon the variation of solution pH and glucose concentrations, interpolymer complex micelles fabricated via reversible covalent bond formation between PAPBA and PAGA blocks exhibit multi-responsiveness to pH and glucose.
Key words: polymer chemistry; complex micelles; scientific experiment method; reversible covalent bond; multi-responsiveness
发表期数: 2011年4月第7期
引用格式: 王頔,刘世勇. 基于葡萄糖和苯硼酸基元间可逆共价键构筑多重响应性高分子复合物胶束[J]. 中国科技论文在线精品论文,2011,4(7):610-618.
 
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