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基于遥控释药胶囊的卡马西平肠吸收药动学研究

发表时间:2011-06-15  浏览量:1367  下载量:588
全部作者: 贾子如,刘洪英,皮喜田,郑小林,唐伟
作者单位: 重庆大学生物工程学院;重庆大学光电工程学院微系统研究中心;第三军医大学西南医院设备科
摘 要: 目的:研究卡马西平(carbamazepine, CBZ)在健康志愿者近端小肠吸收的药代动力学,了解其定位吸收的体内分布和消除规律。方法:用自主研制的遥控释药胶囊系统,将200 mg CBZ定位释放于志愿者的近端小肠内。用荧光偏振免疫分析仪(TDx,美国雅培)测定CBZ的血药浓度,3P87程序拟合房室模型并计算药代动力学参数。结果:健康志愿者近端小肠定点吸收卡马西平的药-时曲线符合一房室开放模型,主要药动学参数:最大血药浓度(Cmax)为(2.1±0.3)mg·L-1;药峰时间(Tmax)为(8.6±2.4)h;半衰期(T1/2)为(6.9±1.6)h;曲线下面积(AUC(0~36))为(33±8)mg·L-1·h-1. 结论:CBZ在志愿者近端小肠定点释放后吸收速率缓慢,吸收总量较好。
关 键 词: 生物药物学;卡马西平;遥控释药胶囊;肠吸收;药代动力学
Title: Study on pharmacokinetics of carbamazepine in the small intestine based on remote controlled capsule
Author: JIA Ziru, LIU Hongying, PI Xitian, ZHENG Xiaolin, TANG Wei
Organization: College of Bioengineering, Chongqing University; Microsystem Research Center, College of Optoelectronic Engineering, Chongqing University; Department of Equipment, Southwest Hospital, The Third Military Medical University
Abstract: Objective: To investigate the pharmacokinetics of carbamazepine (CBZ) in the proximal small intestine of healthy volunteers and obtain the standard pharmacokinetic parameters. Methods: 200 mg CBZ was delivered in the proximal small intestine of healthy volunteers by remote controlled capsule system, which made by our work group. The concentration of CBZ in serum was determined by TDx. The main parameters were calculated by 3P87 pharmacokinetic program. Results: The CBZ pharmacokinetics conforms to a one-compartment open model after a single delivered dose of CBZ (200 mg) in upper small intestine of healthy volunteers. The main parameters were as follows: Cmax was (2.1±0.3) mg·L-1, Tmax was (8.6±2.4) h,T1/2 was (6.9±1.6) h, AUC(0~36) was (33±8) mg·L-1·h-1. Conclusion: The pharmacokinetics of CBZ showed that there were slow and good absorption in upper small intestine of healthy volunteers.
Key words: biological pharmacology; carbamazepine; remote controlled capsule; intestinal absorption; pharmacokinetics
发表期数: 2011年6月第11期
引用格式: 贾子如,刘洪英,皮喜田,等. 基于遥控释药胶囊的卡马西平肠吸收药动学研究[J]. 中国科技论文在线精品论文,2011,4(11):963-966.
 
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