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同型半胱氨酸与心脑血管疾病的关系及致病机理

发表时间:2011-10-15  浏览量:1392  下载量:650
全部作者: 黄涛,李铎
作者单位: 浙江大学生物系统工程与食品科学学院,亚太临床营养学会营养与食品安全中心
摘 要: 同型半胱氨酸(homocystine,Hcy)通过参与氧化反应产生超氧化物及过氧化物损伤血管内皮细胞,从而改变凝血因子功能,引起血管壁巨噬细胞反应,造成血管壁脂肪堆积等,但其对心脑血管疾病的治病机理尚不清楚。综述并分析了近几十年的相关研究成果,重点分析同型半胱氨酸的代谢及其在心脑血管等疾病发生和发展中的致病机理。最后,对高同型半胱氨酸血症(hyperhomocystcinemia,HHcy)的预防进行阐述。
关 键 词: 食品营养学;同型半胱氨酸;综述;致病机理;心脑血管疾病;高同型半胱氨酸血症
Title: Relationship between Hcy and heart cerebrovascular disease and its pathogenesis
Author: HUANG Tao, LI Duo
Organization: Asia-Pacific Clinical Nutrition Society Centre of Nutrition and Food Safety, School of Biosystems Engineering and Food Science, Zhejiang University
Abstract: Increased plasma homocysteine (Hcy) takes a part in oxidizing reaction and produces superoxide and peroxide damaging endothelial cells of blood vessels, changing functions of blood coagulation factors, inducing vascular wall macrophages reaction and causing vascular wall adipose accumulation. The mechanism of Hcy on heart cerebrovascular disease pathogenesis still remains a mystery in many aspects. More studies are needed to further clarify the heart cerebrovascular disease pathogenesis of hyperhomocysteinemia. The aim of this review paper is to summarize the role of elevated Hcy levels in heart cerebrovascular disease and other diseases and the molecular mechanisms and pathophysiology involved in deleterious manifestations of hyperhomocysteinemia (HHcy).
Key words: food nutriology; homocysteine; reviews; pathogenesis; heart cerebrovascular disease; hyperhomocysteinemia
发表期数: 2011年10月第19期
引用格式: 黄涛,李铎. 同型半胱氨酸与心脑血管疾病的关系及致病机理[J]. 中国科技论文在线精品论文,2011,4(19):1791-1798.
 
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