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PPARγ在乳腺癌中的表达和意义

发表时间:2011-12-15  浏览量:1072  下载量:504
全部作者: 邹琳,江颖
作者单位: 盐城市第一人民医院病理科;复旦大学附属中山医院
摘 要: 目的:探讨过氧化物酶体增殖激活受体γ(peroxisome proliferator-activated receptor γ,PPARγ)在乳腺癌组织中的表达及与乳腺癌临床和预后的关系。方法:采用免疫组织化学法检测70例乳腺癌组织和20例乳腺纤维腺瘤中PPARγ蛋白的表达情况,结合临床病理特征和随访资料进行分析。结果:PPARγ蛋白表达水平与乳腺癌组织学分级、原发肿瘤区域淋巴结远处转移(tumor node metastasis,TNM)分期、淋巴结转移、肿瘤大小负相关(P<0.05),与雌激素受体(estrogen receptor,ER)状态及总体生存率正相关(P<0.01)。结论:PPARγ与乳腺癌发展有关,检测PPARγ表达对判断乳腺癌生物学行为和预后具有参考价值。
关 键 词: 病理学;乳腺肿瘤;过氧化物酶体增殖激活受体γ;免疫组化;预后
Title: Expression and significance of PPARγ in human breast cancer
Author: ZOU Lin, JIANG Ying
Organization: Department of Pathology, Yancheng No.1 People’s Hospital; Zhongshan Hospital, Fudan University
Abstract: Objective: To study the expression of peroxisome proliferator-activated receptor γ (PPARγ) in breast cancer and its correlation with clinicopathological parameters and prognosis. Methods: Tissue samples gotten from 70 patients with breast cancer and 20 patients with breast fibroadenoma were immunohistochemically examined for the expression of PPARγ. Then correlations were analyzed between immunohistochemistry (IHC)-assessed level of PPARγ and major clinicopathological variables and survival. Results: PPARγ expression was inversely associated with histologic grade, tumor size, axillary lymph node metastasis and tumor node metastasis (TNM) stage (P<0.05), while positively correlated with estrogen receptor (ER) status and overall survival rate (P<0.01). Conclusion: PPARγ is correlated with development of breast carcinoma, suggesting that detection of PPARγ may be of value in evaluating the biological behaviors and the prognosis of breast cancer.
Key words: pathology; breast cancer; peroxisome proliferator-activated receptor γ; immunohistochemistry; prognosis
发表期数: 2011年12月第23期
引用格式: 邹琳,江颖. PPARγ在乳腺癌中的表达和意义[J]. 中国科技论文在线精品论文,2011,4(23):2031-2035.
 
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