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基于Arrowsmith探讨黄芪与维生素D轴功能的潜在相关性

发表时间:2011-12-15  浏览量:1132  下载量:506
全部作者: 陈云志,秦钟,王瑶瑶,郭军
作者单位: 贵阳中医学院基础医学院;贵阳中医学院第一临床医学院
摘 要: 目的:研究黄芪与维生素D功效在心血管疾病治疗中的相关性,探讨黄芪治疗心血管疾病可能作用于维生素D轴的分子机制,为黄芪作用于心血管系统的广泛药理作用提供中间环节。方法:运用Arrowsmith工具收集整理资料并进行分析。结果:黄芪与维生素D除调节钙、磷代谢,促进骨发育外,在调节肾素-血管紧张素-醛固酮系统(renin-angiotensin-aldosterone system,RAAS),调节转化生长因子-β(transforming growth factor-β, TGF-β)分泌,平衡炎症细胞因子与抗炎细胞因子,改善胰岛素抵抗等在高血压、左室重塑、心力衰竭、代谢综合征等许多方面具有一定的关联性。结论:黄芪可能部分通过调节维生素D轴(参与维生素D代谢的酶及维生素D受体)发挥广泛药理作用。
关 键 词: 中西医结合医学;黄芪;维生素D;Arrowsmith
Title: Potential correlation between Astragalus and vitamin D axis function based on Arrowsmith
Author: CHEN Yunzhi, QIN Zhong, WANG Yaoyao, GUO Jun
Organization: School of Basic Medical Sciences, Guiyang College of Traditional Chinese Medicine; The First Clinical Medical College, Guiyang College of Traditional Chinese Medicine
Abstract: Objective: To study the possible pharmacological effects of Astragalus and vitamin D in treatment of cardiovascular diseases, and discuss the molecular mechanism of extensive pharmacological effects of Astragalus on cardiovascular system may contribute to vitamin D axis. Methods: Arrowsmith tool was used for collecting data and performing analysis. Results: Astragalus and vitamin D had some relevance in regulating renin-angiotensin-aldosterone-system (RAAS), regulating transforming growth factor-β (TGF-β) secretion, balancing inflammatory cytokines and anti-inflammatory cytokines and improving insulin resistance in hypertension, left ventricular remodeling, heart failure, metabolic syndrome as well as in regulating calcium and phosphorus metabolism and promoting bone growth. Conclusion: Astragalus may have a wide range of pharmacological effects by partially regulating vitamin D axis (enzyme and vitamin D receptors involved in vitamin D metabolism).
Key words: integrated traditional Chinese and western medicine; Astragalus; vitamin D; Arrowsmith
发表期数: 2011年12月第23期
引用格式: 陈云志,秦钟,王瑶瑶,等. 基于Arrowsmith探讨黄芪与维生素D轴功能的潜在相关性[J]. 中国科技论文在线精品论文,2011,4(23):2192-2196.
 
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