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基于Arrowsmith探讨黄芪与维生素D轴功能的潜在相关性
发表时间：2011-12-15 浏览量：1616 下载量：667
| 全部作者： | 陈云志，秦钟，王瑶瑶，郭军 |
| 作者单位： | 贵阳中医学院基础医学院；贵阳中医学院第一临床医学院 |
| 摘 要： | 目的：研究黄芪与维生素D功效在心血管疾病治疗中的相关性，探讨黄芪治疗心血管疾病可能作用于维生素D轴的分子机制，为黄芪作用于心血管系统的广泛药理作用提供中间环节。方法：运用Arrowsmith工具收集整理资料并进行分析。结果：黄芪与维生素D除调节钙、磷代谢，促进骨发育外，在调节肾素-血管紧张素-醛固酮系统（renin-angiotensin-aldosterone system，RAAS），调节转化生长因子-β(transforming growth factor-β, TGF-β)分泌，平衡炎症细胞因子与抗炎细胞因子，改善胰岛素抵抗等在高血压、左室重塑、心力衰竭、代谢综合征等许多方面具有一定的关联性。结论：黄芪可能部分通过调节维生素D轴（参与维生素D代谢的酶及维生素D受体）发挥广泛药理作用。 |
| 关 键 词： | 中西医结合医学；黄芪；维生素D；Arrowsmith |
| Title： | Potential correlation between Astragalus and vitamin D axis function based on Arrowsmith |
| Author： | CHEN Yunzhi, QIN Zhong, WANG Yaoyao, GUO Jun |
| Organization： | School of Basic Medical Sciences, Guiyang College of Traditional Chinese Medicine; The First Clinical Medical College, Guiyang College of Traditional Chinese Medicine |
| Abstract： | Objective: To study the possible pharmacological effects of Astragalus and vitamin D in treatment of cardiovascular diseases, and discuss the molecular mechanism of extensive pharmacological effects of Astragalus on cardiovascular system may contribute to vitamin D axis. Methods: Arrowsmith tool was used for collecting data and performing analysis. Results: Astragalus and vitamin D had some relevance in regulating renin-angiotensin-aldosterone-system (RAAS), regulating transforming growth factor-β (TGF-β) secretion, balancing inflammatory cytokines and anti-inflammatory cytokines and improving insulin resistance in hypertension, left ventricular remodeling, heart failure, metabolic syndrome as well as in regulating calcium and phosphorus metabolism and promoting bone growth. Conclusion: Astragalus may have a wide range of pharmacological effects by partially regulating vitamin D axis (enzyme and vitamin D receptors involved in vitamin D metabolism). |
| Key words： | integrated traditional Chinese and western medicine; Astragalus; vitamin D; Arrowsmith |
| 发表期数： | 2011年12月第23期 |
| 引用格式： | 陈云志，秦钟，王瑶瑶，等. 基于Arrowsmith探讨黄芪与维生素D轴功能的潜在相关性[J]. 中国科技论文在线精品论文，2011，4（23）：2192-2196. |
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