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c-Myc与核呼吸因子-1在细胞凋亡中的作用

发表时间:2012-06-15  浏览量:1312  下载量:433
全部作者: 桑灏,张丽娟,李觉
作者单位: 同济大学医学院
摘 要: 细胞凋亡影响着诸多疾病的发生与转归,原癌蛋白(c- Myc)与核呼吸因子- 1(nuclear respiratory factor- 1,NRF- 1)均参与了细胞凋亡的信号通路。主要从c- Myc介导的细胞凋亡、NRF- 1介导的线粒体功能损伤和c- Myc与NRF- 1协同作用对细胞凋亡的影响这3方面,综述c- Myc与NRF- 1在细胞凋亡中的作用。研究发现:c- Myc和NRF- 1可能竞争结合细胞色素C上的结合位点,从而在细胞凋亡通路中发挥作用。探讨c- Myc与NRF- 1在凋亡通路中的单独与交互作用,将有助于更好地了解细胞凋亡与存活的相关机制。
关 键 词: 毒理学;细胞凋亡;综述;c- Myc原癌蛋白;核呼吸因子- 1
Title: Function of c-Myc and nuclear respiratory factor-1 in cell apoptosis
Author: SANG Hao, ZHANG Lijuan, LI Jue
Organization: Medical School, Tongji University
Abstract: Apoptosis affects the morbidity and prognosis of many diseases. Both c- Myc and nuclear respiratory factor- 1(NRF- 1) are involved in the cellular apoptotic signaling pathway. Based on the introduction of c- Myc- induced cellular apoptosis, NRF- 1- mediated mitochondria injury and the synergistic effect of c- Myc and NRF- 1 in cellular apoptosis, this paper summarizes the function of c- Myc and NRF- 1 in cellular apoptosis. Studies have indicated that c- Myc and NRF- 1 may combine cytochrome C competitively in the process of cell survival and apoptosis. The study c- Myc and NRF- 1, as well as their possible interaction may conduce to better understanding of the mechanism of cell survival and apoptosis.
Key words: toxicology; apoptosis; reviews; c- Myc oncoprotein; nuclear respiratory factor- 1
发表期数: 2012年6月第11期
引用格式: 桑灏,张丽娟,李觉. c-Myc与核呼吸因子-1在细胞凋亡中的作用[J]. 中国科技论文在线精品论文,2012,5(11):1024-1030.
 
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