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TCRP1在口腔鳞癌中介导顺铂耐药的体内实验研究

发表时间:2012-06-15  浏览量:1141  下载量:525
全部作者: 谷依学,贺智敏
作者单位: 广州医学院附属肿瘤医院肿瘤研究所;中南大学湘雅医学院肿瘤研究所
摘 要: 舌癌耐药相关基因1(TCRP1)是新近从舌癌耐药细胞系Tca8113/PYM中克隆出来的一个新基因,生物信息学分析结果显示:TCRP1基因定位于染色体11q13.4,编码由235个氨基酸组成的蛋白质,蛋白质分子量约25 ku. 初步功能研究结果显示:在舌癌细胞系Tca8113中,TCRP1能特异性地介导顺铂耐药,推测TCRP1可能是一个顺铂耐药相关基因。基于以上体外实验结果,通过建立TCRP1过/沉默表达裸鼠移植瘤模型,探讨了TCRP1在体内实验中的作用及其介导顺铂耐药的可能机制。
关 键 词: 肿瘤学;口腔鳞癌;顺铂;耐药;舌癌耐药相关基因1;凋亡
Title: Effect in vivo of TCRP1 mediating resistance to cisplatin in OSCC
Author: GU Yixue, HE Zhimin
Organization: Cancer Research Institute, Cancer Institute and Hospital, Guangzhou Medical University; Cancer Research Institute, Xiangya School of Medicine, Central South University
Abstract: TCRP1 is a novel gene which was cloned from a multi- drug resistant cell line Tca8113/PYM in previous research. The results of bioinformatics indicated that TCRP1 was located on human chromosome 11q13.4, and encoded a putative protein of 235 amino acids with molecular weight of 25 ku. The preliminary functional investigation indicated that TCRP1 was a new chemo- resistance related gene, which mediated specifically resistance to cisplatin in oral squamous cell carcinoma (OSCC) cells. This paper identified the effect in vivo and the possible mechanism through establishing the ectopic tumor animal model of over/silence expression of TCRP1.
Key words: oncology phymatology; oral squamous cell carcinoma; cisplatin; resistance; TCRP1; apoptosis
发表期数: 2012年6月第11期
引用格式: 谷依学,贺智敏. TCRP1在口腔鳞癌中介导顺铂耐药的体内实验研究[J]. 中国科技论文在线精品论文,2012,5(11):1047-1053.
 
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