您的位置:首页  > 论文页面

乳腺癌中PR的表达及其与TNF-α相关性研究

发表时间:2012-06-15  浏览量:1047  下载量:517
全部作者: 喻明霞
作者单位: 武汉大学中南医院检验科&基因检测中心
摘 要: 目的:研究乳腺癌中孕激素受体(progesterone receptor,PR)的表达及其与肿瘤坏死因子- α(tumor necrosis factor- α, TNF- α)的相关性。方法:采用免疫组织化学(strept avidin- biotin complex,SABC)法检测112例原发性乳腺癌组织中PR,TNF- α的表达,分析PR与乳腺癌临床病理特征的关系以及PR和TNF- α的相关性。结果:1) 乳腺癌中PR的阳性表达率为23.21%(26/112);2) PR在乳腺癌中的表达与TNM分期、年龄、初潮年龄、是否绝经、孕次、产次、肿瘤家族史均无相关性(P>0.05);3) PR与TNF- α在乳腺癌中的表达有显著正相关性(P<0.05)。结论:PR与乳腺癌多项临床病理特征无显著相关性,与TNF- α在乳腺癌中的表达显著正相关,具体机制有待进一步研究。
关 键 词: 实验诊断学;孕激素受体;肿瘤坏死因子- α;乳腺癌
Title: Expressions of progesterone receptor and correlations with tumor necrosis factor-α in breast cancer
Author: YU Mingxia
Organization: Department of Clinical Laboratory & Genetic Testing Center, Zhongnan Hospital of Wuhan University
Abstract: Objective: To determine the expression of progesterone receptor (PR) in breast cancer and its correlation with tumor necrosis factor- α (TNF- α). Methods: Strept avidin- biotin complex (SABC) method was used to detect the expressions of PR and TNF- α in 112 cases of primary breast cancer, and analyzed the association of PR with clinicopathological features of breast cancer and TNF- α. Results: 1) The positive expression rate of PR in breast cancer was 23.21%(26/112). 2) There were no significant associations of PR with TNM staging, age, age of menarche, menopause, gravidity, parity and family history of cancer. 3) PR had a positive correlation with TNF- α in breast cancer (P<0.05). Conclusion: There was no significant association of PR with clinicopathological features of breast cancer. PR had a positive correlation with TNF- α in breast cancer, but the specific mechanism needs follow- up research.
Key words: laboratory diagnostics; progesterone receptor; tumor necrosis factor- α; breast cancer
发表期数: 2012年6月第11期
引用格式: 喻明霞. 乳腺癌中PR的表达及其与TNF-α相关性研究[J]. 中国科技论文在线精品论文,2012,5(11):1054-1057.
 
0 评论数 0
暂无评论
友情链接