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靶向CCR5的HIV基因治疗研究进展

发表时间:2012-12-15  浏览量:1418  下载量:651
全部作者: 汝任礼,游剑岚,秦莉,陈小平
作者单位: 中科院广州生物医药与健康研究院感染与免疫研究中心;中国科技大学生命科学学院
摘 要: 趋化因子受体CCR5是人类免疫缺陷病毒(human immunodeficiency virus,HIV)的主要共受体,它的缺失使HIV不能感染靶细胞,因而成为治疗HIV/艾滋病(acquired immune deficiency syndrome,AIDS)的重要靶点。综述了近年来以CCR5为靶点,利用胞内因子、胞内抗体、siRNA、核酶、锌指核酸酶(zinc finger nuclease,ZFN)、肽核酸(peptide nucleic acid,PNA)技术等手段在HIV的基因治疗领域中所取得的实验进展和部分临床研究成果,并探讨了这些治疗策略在临床应用中的问题与前景,为利用靶向CCR5基因治疗手段治疗AIDS提供了详细的理论参考。
关 键 词: 医学微生物学;人类免疫缺陷病毒;综述;CCR5;基因治疗
Title: Research advances in targeting CCR5 for HIV gene therapy
Author: RU Renli, YOU Jianlan, QIN Li, CHEN Xiaoping
Organization: Center for Infection and Immunity, Guangzhou Institutes of Biomedicine and Health, Chinese Adademy of Sciences; School of Life Science, University of Science and Technology of China
Abstract: Chemokine recptor CCR5 is a main coreceptor of human immunodeficiency virus (HIV), lack of CCR5 will disable HIV for infection of target cells,which makes it an important target for HIV/acquired immune deficiency syndrome (AIDS) treatments. This review summarized the development of basical research and some clinical research on targeting CCR5 in HIV gene therapy fields, by using intrakine,intrabody,small interfering RNA, ribozyme,zinc finger nuclease (ZFN) and peptide nucleic acid (PNA) techniques. Furthermore, the problems and prospects of these strategies in clinical application were discussed. This review provides detailed theoretical references for AIDS gene therapy using targeting CCR5.
Key words: medical microbiology; human immunodeficiency virus; reviews; CCR5; gene therapy
发表期数: 2012年12月第23期
引用格式: 汝任礼,游剑岚,秦莉,等. 靶向CCR5的HIV基因治疗研究进展[J]. 中国科技论文在线精品论文,2012,5(23):2213-2220.
 
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