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HBV感染状态下PD1/PD-L1的表达研究

发表时间:2012-12-15  浏览量:1185  下载量:349
全部作者: 张文瑾
作者单位: 浙江大学医学院附属第一医院肝胆胰外科
摘 要: 以慢性肝炎活动状态的患者为研究对象,根据转氨酶和肝组织CD8+淋巴细胞的浸润数,将炎症时段分为1至4期,其中于炎症高峰期,程序性死亡受体1(PD1)和其配体PD-L1的表达水平最高;随着炎症程度的降低,PD1和PD-L1的表达水平也随之下降。而且,正负协同刺激分子在细胞水平均呈共表达状态。实验结果表明:在免疫炎症反应过程中,正负协同刺激分子的表达处于平衡状态,免疫抑制受体的高表达是限制炎症反应程度的需要,而非特异性地抑制乙肝病毒(hepatitis B virus,HBV)特异性免疫应答。
关 键 词: 免疫病理学;乙型肝炎;程序性死亡受体1;程序性死亡配体1;免疫组化;免疫耐受
Title: Study on PD1/PD-L1 expression in chronic hepatitis B patients
Author: ZHANG Wenjin
Organization: Department of Hepatopancreat Obliliary, First Affiliated Hospital, School of Medicine, Zhejiang University
Abstract: In this study, the chronic active hepatitis patients were taken as research objects. According to the infiltration number of transaminases and CD8+ lymphocytes in liver tissue, the inflammation period was divided into four phases. The results showed that the expression of PD-1/PD-L1 was up-regulated significantly in inflammation flare-up period. With the reduction of inflammation, the expression level of PD-1 and PD-L1 decreased. Furthermore, PD-1 and PD-L1 were co-expressed with their positive costimulatory partner. These results suggested that the up-regulation of negative costimulatory molecules were needed during inflammation period to maintain homeostasis by the balance of positive-costimulatory signals, rather than specifically inhibit hepatitis B virus (HBV)-specific immune response.
Key words: immunopathology; hepatitis B; PD1; PD-L1; immunohistochemistry; immune tolerance
发表期数: 2012年12月第23期
引用格式: 张文瑾. HBV感染状态下PD1/PD-L1的表达研究[J]. 中国科技论文在线精品论文,2012,5(23):2238-2242.
 
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