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HBV感染状态下PD1/PD-L1的表达研究
发表时间：2012-12-15 浏览量：1726 下载量：431
| 全部作者： | 张文瑾 |
| 作者单位： | 浙江大学医学院附属第一医院肝胆胰外科 |
| 摘 要： | 以慢性肝炎活动状态的患者为研究对象，根据转氨酶和肝组织CD8+淋巴细胞的浸润数，将炎症时段分为1至4期，其中于炎症高峰期，程序性死亡受体1（PD1）和其配体PD-L1的表达水平最高；随着炎症程度的降低，PD1和PD-L1的表达水平也随之下降。而且，正负协同刺激分子在细胞水平均呈共表达状态。实验结果表明：在免疫炎症反应过程中，正负协同刺激分子的表达处于平衡状态，免疫抑制受体的高表达是限制炎症反应程度的需要，而非特异性地抑制乙肝病毒（hepatitis B virus，HBV）特异性免疫应答。 |
| 关 键 词： | 免疫病理学；乙型肝炎；程序性死亡受体1；程序性死亡配体1；免疫组化；免疫耐受 |
| Title： | Study on PD1/PD-L1 expression in chronic hepatitis B patients |
| Author： | ZHANG Wenjin |
| Organization： | Department of Hepatopancreat Obliliary, First Affiliated Hospital, School of Medicine, Zhejiang University |
| Abstract： | In this study, the chronic active hepatitis patients were taken as research objects. According to the infiltration number of transaminases and CD8+ lymphocytes in liver tissue, the inflammation period was divided into four phases. The results showed that the expression of PD-1/PD-L1 was up-regulated significantly in inflammation flare-up period. With the reduction of inflammation, the expression level of PD-1 and PD-L1 decreased. Furthermore, PD-1 and PD-L1 were co-expressed with their positive costimulatory partner. These results suggested that the up-regulation of negative costimulatory molecules were needed during inflammation period to maintain homeostasis by the balance of positive-costimulatory signals, rather than specifically inhibit hepatitis B virus (HBV)-specific immune response. |
| Key words： | immunopathology; hepatitis B; PD1; PD-L1; immunohistochemistry; immune tolerance |
| 发表期数： | 2012年12月第23期 |
| 引用格式： | 张文瑾. HBV感染状态下PD1/PD-L1的表达研究[J]. 中国科技论文在线精品论文，2012，5（23）：2238-2242. |
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