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Pygo2促进转基因小鼠乳腺癌干细胞扩增

发表时间:2013-03-15  浏览量:906  下载量:317
全部作者: 骆启聪,李超,叶国栋,李博安
作者单位: 厦门大学生命科学学院;厦门大学附属第一医院中心实验室
摘 要: 目的:通过Pygo2转基因小鼠模型研究Pygo2蛋白在乳腺癌发生中的作用。方法:构建K14-2×flag-Pygo2的转基因小鼠,比较分析其乳腺发育、乳腺癌干细胞比例、乳腺癌发生的变化。结果:与野生型小鼠相比,Pygo2转基因小鼠的乳腺发育、乳腺癌干细胞比例、乳腺癌发生均发生改变。结论:Pygo2蛋白在小鼠乳腺癌发生发展中发挥重要作用。
关 键 词: 肿瘤学;Pygo2;转基因小鼠;乳腺癌干细胞
Title: Pygo2 promotes the amplification of breast cancer stem cells in transgenic mouse
Author: LUO Qicong, LI Chao, YE Guodong, LI Boan
Organization: School of Life Science, Xiamen University; Center Laboratory, the Fist Affiliated Hospital of Xiamen University
Abstract: Objective: To investigate the function of Pygo2 protein on regulating tumorigenesis of breast cancer in Pygo2-transgenic mice. Methods: K14-2譮lag-Pygo2-transgenic mice were established, and the mammogenesis, breast cancer stem cells population and incidence of breast cancer were examined. Results: The mammogenesis, percentage of breast cancer stem cell population and incidence of breast cancer in Pygo2-transgenic mice were all different from those in wild-type littermates. Conclusion: Pygo2 protein plays an important role in the process of tumorigenesis of breast cancer.
Key words: oncology; Pygo2; transgenic mouse; breast cancer stem cell
发表期数: 2013年3月第5期
引用格式: 骆启聪,李超,叶国栋,等. Pygo2促进转基因小鼠乳腺癌干细胞扩增[J]. 中国科技论文在线精品论文,2013,6(5):455-461.
 
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